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Contents Volume V Issue I (Winter 2020)

 
Fragment-Based Approach towards the Design of Potent and Versatile Anti-Cancer Agents
Abstract:   Despite years of clinical research and trials of encouraging new therapies, cancer remains a leading cause of morbidity and mortality. The fragment-based drug discovery has evolved formerly as an efficient approach for identification, optimization, and generation of lead. After identifying the fragments having binding affinity with the target using computational method for fragment screening, the ...Read More - Download PDF - View Fulltext
Author/s: 1- Sana Ali Zahra
Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

2-Ayesha Imran
Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

3-Faiza Khalid
Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

4-Mubashir Rehman
Assistant Professor, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Keywords:Fragment-Based Drug Design, Potent and Novel Anti-Cancer Agents, Fragment Optimization, Deconstruction-Reconstruction
DOI Number:10.31703/gdddr.2020(V-I).01 DOI Link:http://dx.doi.org/10.31703/gdddr.2020(V-I).01
Page Nos:1-14 Volume & Issue:V-I
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Design of Hollow Nanocapsules and their Applications in Biomedical Imaging
Abstract:  Different nanocarrier systems owing to their nano size, increased surface area and unique electrical and magnetic properties are employed for biomedical applications. Among the various nanocarrier systems, hollow nanocapsules are one of the most interesting carrier systems for thier use in bioimaging and biomedical applications. The unique properties of hollow nanocapsules make them suitable for u ...Read More - Download PDF - View Fulltext
Author/s: 1-Aimen Qaiser
MPhil Candidate, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

2-Muhammad Rauf ul Hassan
Associate Professor, Department of Pulmonology, Quaid-i-Azam Medical College, Bahawalpur Victoria Hospital, Bahawalpur, Punjab, Pakistan.

3-Maria Hassan Kiani
PhD Candidate, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

4-Husna Khalid
MPhil Candidate, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

5-Gul Shahnaz
Chairperson/ Associate Professor, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Keywords:Biomedical Applications, Bioimaging, Hollow Nanocapsules, Imaging Probes, Nanocarriers
DOI Number:10.31703/gdddr.2020(V-I).02 DOI Link:http://dx.doi.org/10.31703/gdddr.2020(V-I).02
Page Nos:15-24 Volume & Issue:V-I
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Conventional and Novel Treatment Strategies to Combat COVID-19 along with Review of most Affected Countries
Abstract:  This review illustrates a comparison of currently implemented strategies and the need of a novel technique to cure the COVID-19. Current strategies served a lot to cope up with the situation by decreasing the rate of fatalities i.e. some FDA approved drugs and giving immunity by the plasma proteins of cured patients, however these approaches could not eliminate the pandemic from the society emphas ...Read More - Download PDF - View Fulltext
Author/s: 1-Umair-Ul-Hassan
Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

2-Rana Muhammad Awais Khan
Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

3-Shafiq-Ur-Rehman
Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

4-Amjad Khan
Assistant Professor, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Keywords:CRISPR-Cas, Cure, Covid-19, FDA, SARS-COV-2
DOI Number:10.31703/gdddr.2020(V-I).03 DOI Link:http://dx.doi.org/10.31703/gdddr.2020(V-I).03
Page Nos:25-32 Volume & Issue:V-I
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Approaches of Prodrug Designing to Treat Cancer, Neurodegenerative Disorders and Viral Diseases
Abstract:   Classical prodrug design is a sweeping approach to throw away futile side effects related to drug therapy. The main purpose of prodrug designing is to ameliorate physicochemical, pharmaceutical, and pharmacokinetic characteristics of particular compounds to resolve issues like formulation, delivery to the target site, and toxicity limitations. To fabricate the pharmacological action in CNS, drugs ...Read More - Download PDF - View Fulltext
Author/s: 1-Muhammad Shehzeb Ashraf
Undergraduate Final year students, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

2-Iqra Rehman
Undergraduate Final year students, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

3-Urooj Fatima
Undergraduate Final year students, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

4-Mubashar Rehman
Assistant Professor, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Keywords:Cytochrome P450, Doxorubicin, Drug Delivery, Blood-Brain Barrier, Prodrug Design, Levodopa
DOI Number:10.31703/gdddr.2020(V-I).04 DOI Link:http://dx.doi.org/10.31703/gdddr.2020(V-I).04
Page Nos:33-47 Volume & Issue:V-I
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Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review
Abstract:  Carbon nanotubes are one of the most widely investigated carbon structures because of variety of physicochemical features offered by them. Their dimensions, surface chemistry and functionalization opportunities make them exceptional carrier for targeted drug delivery gene therapy, diagnosis and cell imaging. Both single and multi-walled CNTs have been functionalized for therapeutic applications. ...Read More - Download PDF - View Fulltext
Author/s: 1-Maria Hassan Kiani
PhD Candidate, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

2-Ayesha Batool
MPhil, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

3-Maheen Khurshid
MPhil, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

4-Memoona Kanwal
MPhil, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

5-Naveed Ahmed
Assistant Professor, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
Keywords:Carbon Nanotubes, Toxicity, Organ Specific, Mechanisms, Functionalization
DOI Number:10.31703/gdddr.2020(V-I).05 DOI Link:http://dx.doi.org/10.31703/gdddr.2020(V-I).05
Page Nos:48-57 Volume & Issue:V-I
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