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Volume-V

, Issue-I

(FALL 2020)

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01 - Fragment-Based Approach towards the Design of Potent and Versatile Anti-Cancer A

http://dx.doi.org/10.31703/gdddr.2020(V-I).01
10.31703/gdddr.2020(V-I).01
Published : Dec 2020

Abstract

    Despite years of clinical research and trials of encouraging new therapies, cancer remains a leading cause of morbidity and mortality. The fragment-based drug discovery has evolved formerly as an efficient approach for identification, optimization, and generation of lead. After identifying the fragments having binding affinity with the target using computational method for fragment screening, they... Details

    Fragment-Based Drug Design, Potent and Novel Anti-Cancer Agents, Fragment Optimization, Deconstruction-Reconstruction

    (1) Sana Ali Zahra
    Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Ayesha Imran
    Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Faiza Khalid
    Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
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02 - Design of Hollow Nanocapsules and their Applications in Biomedical Imaging

http://dx.doi.org/10.31703/gdddr.2020(V-I).02
10.31703/gdddr.2020(V-I).02
Published : Dec 2020

Abstract

    Different nanocarrier systems owing to their nano size, increased surface area and unique electrical and magnetic properties are employed for biomedical applications. Among the various nanocarrier systems, hollow nanocapsules are one of the most interesting carrier systems for thier use in bioimaging and biomedical applications. The unique properties of hollow nanocapsules make them suitable for u... Details

    Biomedical Applications, Bioimaging, Hollow Nanocapsules, Imaging Probes, Nanocarriers

    (1) Aimen Qaiser
    MPhil Candidate, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Muhammad Rauf ul Hassan
    Associate Professor, Department of Pulmonology, Quaid-i-Azam Medical College, Bahawalpur Victoria Hospital, Bahawalpur, Punjab, Pakistan.
    (3) Maria Hassan Kiani
    PhD Candidate, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
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03 - Conventional and Novel Treatment Strategies to Combat COVID-19 along with Review

http://dx.doi.org/10.31703/gdddr.2020(V-I).03
10.31703/gdddr.2020(V-I).03
Published : Dec 2020

Abstract

    This review illustrates a comparison of currently implemented strategies and the need of a novel technique to cure the COVID-19. Current strategies served a lot to cope up with the situation by decreasing the rate of fatalities i.e. some FDA approved drugs and giving immunity by the plasma proteins of cured patients, however these approaches could not eliminate the pandemic from the society emphas... Details

    CRISPR-Cas, Cure, Covid-19, FDA, SARS-COV-2

    (1) Umair-Ul-Hassan
    Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Rana Muhammad Awais Khan
    Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Shafiq-Ur-Rehman
    Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
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04 - Approaches of Prodrug Designing to Treat Cancer, Neurodegenerative Disorders and

http://dx.doi.org/10.31703/gdddr.2020(V-I).04
10.31703/gdddr.2020(V-I).04
Published : Dec 2020

Abstract

    Classical prodrug design is a sweeping approach to throw away futile side effects related to drug therapy. The main purpose of prodrug designing is to ameliorate physicochemical, pharmaceutical, and pharmacokinetic characteristics of particular compounds to resolve issues like formulation, delivery to the target site, and toxicity limitations. To fabricate the pharmacological action in CNS, drugs ... Details

    Cytochrome P450, Doxorubicin, Drug Delivery, Blood-Brain Barrier, Prodrug Design, Levodopa

    (1) Muhammad Shehzeb Ashraf
    Undergraduate Final year students, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Iqra Rehman
    Undergraduate Final year students, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Urooj Fatima
    Undergraduate Final year students, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
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05 - Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review

http://dx.doi.org/10.31703/gdddr.2020(V-I).05
10.31703/gdddr.2020(V-I).05
Published : Dec 2020

Abstract

    Carbon nanotubes are one of the most widely investigated carbon structures because of variety of physicochemical features offered by them. Their dimensions, surface chemistry and functionalization opportunities make them exceptional carrier for targeted drug delivery gene therapy, diagnosis and cell imaging. Both single and multi-walled CNTs have been functionalized for therapeutic applications. H... Details

    Carbon Nanotubes, Toxicity, Organ Specific, Mechanisms, Functionalization

    (1) Maria Hassan Kiani
    PhD Candidate, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Ayesha Batool
    MPhil, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Maheen Khurshid
    MPhil, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
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