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ORGAN SPECIFIC TOXICITY OF SINGLE AND MULTIWALLED CARBON NANOTUBES A REVIEW

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05 Pages : 48-57

http://dx.doi.org/10.31703/gdddr.2020(V-I).05      10.31703/gdddr.2020(V-I).05      Published : Dec 2020

Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review

Abstract

    Carbon nanotubes are one of the most widely investigated carbon structures because of variety of physicochemical features offered by them. Their dimensions, surface chemistry and functionalization opportunities make them exceptional carrier for targeted drug delivery gene therapy, diagnosis and cell imaging. Both single and multi-walled CNTs have been functionalized for therapeutic applications. However, these structures have been associated with potential in vitro and in vivo cytotoxic effects. Such toxicities have been described to involve both cellular and subcellular mechanisms. Major organs that have shown significant CNTs related toxic effects include lungs, brain, heart, kidney, liver and skin. This review focuses on the potential toxicological effects of single and multi-walled carbon nanotubes and functionalization on these organs and associated mechanisms of toxicity

    Carbon Nanotubes, Toxicity, Organ Specific, Mechanisms, Functionalization

    (1) Maria Hassan Kiani
    PhD Candidate, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Ayesha Batool
    MPhil, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Maheen Khurshid
    MPhil, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (4) Memoona Kanwal
    MPhil, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (5) Naveed Ahmed
    Assistant Professor, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
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Cite this article

APA

    APA : Kiani, M. H., Batool, A., & Khurshid, M. (2020). Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review. Global Drug Design & Development Review, V(I), 48-57. https://doi.org/10.31703/gdddr.2020(V-I).05

CHICAGO

    CHICAGO : Kiani, Maria Hassan, Ayesha Batool, and Maheen Khurshid. 2020. "Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review." Global Drug Design & Development Review, V (I): 48-57 doi: 10.31703/gdddr.2020(V-I).05

HARVARD

    HARVARD : KIANI, M. H., BATOOL, A. & KHURSHID, M. 2020. Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review. Global Drug Design & Development Review, V, 48-57.

MHRA

    MHRA : Kiani, Maria Hassan, Ayesha Batool, and Maheen Khurshid. 2020. "Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review." Global Drug Design & Development Review, V: 48-57

MLA

    MLA : Kiani, Maria Hassan, Ayesha Batool, and Maheen Khurshid. "Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review." Global Drug Design & Development Review, V.I (2020): 48-57 Print.

OXFORD

    OXFORD : Kiani, Maria Hassan, Batool, Ayesha, and Khurshid, Maheen (2020), "Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review", Global Drug Design & Development Review, V (I), 48-57

TURABIAN

    TURABIAN : Kiani, Maria Hassan, Ayesha Batool, and Maheen Khurshid. "Organ Specific Toxicity of Single and Multi-Walled Carbon Nanotubes: A Review." Global Drug Design & Development Review V, no. I (2020): 48-57. https://doi.org/10.31703/gdddr.2020(V-I).05