ARTICLE

PREVALENCE TREATMENT OUTCOME AND DRUG SUSCEPTIBILITY PATTERN FOR MULTIDRUG RESISTANT TUBERCULOSIS PATIENTS IN THE SOUTHERN REGION OF KHYBER PAKHTUNKHWA PAKISTAN

08 Pages : 59-67

http://dx.doi.org/10.31703/gdddr.2022(VII-II).08      10.31703/gdddr.2022(VII-II).08      Published : Jun 2022

Prevalence, Treatment, Outcome, and Drug Susceptibility Pattern for Multi-Drug Resistant Tuberculosis Patients in the Southern Region of Khyber Pakhtunkhwa, Pakistan

    Tuberculosis is a 5000-year-old bacterial disease and the second leading cause of death. The MDR strain of Mycobacterium Tuberculosis has exacerbated TB's medication resistance in Pakistan. Our study aims to assess the prevalence, treatment outcome, and medication resistance pattern of MDR TB patients in Dere Ismail Khan Mufti Mehmood Hospital's PMDT Unit. From 2013 to March 2019, 298 patients were recorded on PMDT. Our investigation found 10% of MDR TB cases. Among 298 MDR TB patients, 62 (20.8%) are being treated, and all are drug-resistant. Our study had 133 (44.6%) successful treatments. 103 (34.5%) treatments fail. To control the high resistance rate, low treatment success rate, and primary transmission of MDR-TB in D.I.Khan Pakistan, we recommended that each MDR patient support socially, improve living standards, and medical security, and evaluate proper treatment, understand risk factors, and improving treatment outcome.

    Multidrug Resistance, Tuberculosis, Prevalence, Drug Susceptibility
    (1) Faisal Younis
    Physician /Coordinator, Mufti Mehmood Memorial Teaching Hospital, Dera Ismail Khan, KP, Pakistan.
    (2) Muhammad Nadeem
    Regional Blood Centre, Dera Ismail Khan, KP, Pakistan.
    (3) Sajad Ahmad
    Regional Blood Centre, Dera Ismail Khan, KP, Pakistan.
    (4) Husnian Hashim
    Consultant Neurologist and Head of Neurology Department, Fauji Foundation Hospital Rawalpindi, Punjab, Pakistan.
    (5) Raheela Bano
    Assistant Professor Department of Pathology Gomal medical college, , Dera Ismail Khan, KP, Pakistan.
  • Ahmad, N., Javaid, A., Syed Sulaiman, S. A., Basit, A., Afridi, A. K., Jaber, A. A. S., & Khan, A. H. (2016). Effects of multidrug-resistant tuberculosis treatment on patients' health related quality of life: results from a follow up study. PloS one, 11(7), 159-560.
  • Akhtar, A. M., Arif, M. A., Kanwal, S., & Majeed, S. (2016). Prevalence and drug resistance pattern of MDR TB in retreatment cases of Punjab, Pakistan. J Pak Med Assoc, 66(8), 989-3.
  • Ali, S., Khan, M. T., Khan, A. S., Mohammad, N., Khan, M. M., Ahmad, S., ... & Hassan, F. (2020). Prevalence of multi-drug resistant Mycobacterium tuberculosis in Khyber Pakhtunkhwa–a high tuberculosis endemic area of Pakistan. Polish Journal of Microbiology, 69(2), 133-137.
  • Atif, M., Bashir, A., Ahmad, N., Fatima, R. K., Saba, S., & Scahill, S. (2017). Predictors of unsuccessful interim treatment outcomes of multidrug resistant tuberculosis patients. BMC infectious diseases, 17(1), 1-12.
  • Ejaz, M., Siddiqui, A. R., Rafiq, Y., Malik, F., Channa, A., Mangi, R., ... & Hasan, R. (2010). Prevalence of multi-drug resistant tuberculosis in Karachi, Pakistan: identification of at risk groups. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104(8), 511-517.
  • Khan, I., Ahmad, N., Khan, S., Muhammad, S., Khan, S. A., Ahmad, I., ... & Atif, M. (2019a). Evaluation of treatment outcomes and factors associated with unsuccessful outcomes in multidrug resistant tuberculosis patients in Baluchistan province of Pakistan. Journal of infection and public health, 12(6), 809-815.
  • Khan, M. A., Mehreen, S., Basit, A., Khan, R. A., Jan, F., Ullah, I., ... & Javaid, A. (2015). Characteristics and treatment outcomes of patients with multi-drug resistant tuberculosis at a tertiary care hospital in Peshawar, Pakistan. Saudi medical journal, 36(12), 1463-1470.
  • Khan, R. A., Shaikh, A. A., & Bulaadi, G. Q. (2019b). Incidence of multidrug-resistant tuberculosis in Sindh, Pakistan. Cureus, 11(4), 1-15.
  • Kumar, A., Singh, A. K., Upadhyay, V., & Pandey, J. (2018). Epidemiology of multi-drug- resistant tuberculosis in Northern India. Biomedical and Biotechnology Research Journal (BBRJ), 2(2), 112-120
  • Mitnick, C. D., Rodriguez, C. A., Hatton, M. L., Brigden, G., Cobelens, F., Grobusch, M. P., ... & RESIST-TB (Research Excellence to Stop TB Resistance) and GDI (Global Drug Resistant TB Initiative). (2016). Programmatic management of drug-resistant tuberculosis: an updated research agenda. PLoS One, 11(5), 155-968.

Cite this article

    APA : Younis, F., Nadeem, M., & Ahmad, S. (2022). Prevalence, Treatment, Outcome, and Drug Susceptibility Pattern for Multi-Drug Resistant Tuberculosis Patients in the Southern Region of Khyber Pakhtunkhwa, Pakistan. Global Drug Design & Development Review, VII(II), 59-67. https://doi.org/10.31703/gdddr.2022(VII-II).08
    CHICAGO : Younis, Faisal, Muhammad Nadeem, and Sajad Ahmad. 2022. "Prevalence, Treatment, Outcome, and Drug Susceptibility Pattern for Multi-Drug Resistant Tuberculosis Patients in the Southern Region of Khyber Pakhtunkhwa, Pakistan." Global Drug Design & Development Review, VII (II): 59-67 doi: 10.31703/gdddr.2022(VII-II).08
    HARVARD : YOUNIS, F., NADEEM, M. & AHMAD, S. 2022. Prevalence, Treatment, Outcome, and Drug Susceptibility Pattern for Multi-Drug Resistant Tuberculosis Patients in the Southern Region of Khyber Pakhtunkhwa, Pakistan. Global Drug Design & Development Review, VII, 59-67.
    MHRA : Younis, Faisal, Muhammad Nadeem, and Sajad Ahmad. 2022. "Prevalence, Treatment, Outcome, and Drug Susceptibility Pattern for Multi-Drug Resistant Tuberculosis Patients in the Southern Region of Khyber Pakhtunkhwa, Pakistan." Global Drug Design & Development Review, VII: 59-67
    MLA : Younis, Faisal, Muhammad Nadeem, and Sajad Ahmad. "Prevalence, Treatment, Outcome, and Drug Susceptibility Pattern for Multi-Drug Resistant Tuberculosis Patients in the Southern Region of Khyber Pakhtunkhwa, Pakistan." Global Drug Design & Development Review, VII.II (2022): 59-67 Print.
    OXFORD : Younis, Faisal, Nadeem, Muhammad, and Ahmad, Sajad (2022), "Prevalence, Treatment, Outcome, and Drug Susceptibility Pattern for Multi-Drug Resistant Tuberculosis Patients in the Southern Region of Khyber Pakhtunkhwa, Pakistan", Global Drug Design & Development Review, VII (II), 59-67
    TURABIAN : Younis, Faisal, Muhammad Nadeem, and Sajad Ahmad. "Prevalence, Treatment, Outcome, and Drug Susceptibility Pattern for Multi-Drug Resistant Tuberculosis Patients in the Southern Region of Khyber Pakhtunkhwa, Pakistan." Global Drug Design & Development Review VII, no. II (2022): 59-67. https://doi.org/10.31703/gdddr.2022(VII-II).08