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A LITERATURE REVIEW OF THE PHYSICOCHEMICAL PHYSIOLOGICAL AND PHARMACEUTICAL CONSIDERATIONS IN GIT ABSORPTION OF DRUGS

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03 Pages : 18-33

http://dx.doi.org/10.31703/gdddr.2017(II-I).03      10.31703/gdddr.2017(II-I).03      Published : Dec 2017

A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs.

Abstract

    Oral route of drug administration is the most common among all routes and hence their pharmacokinetic and pharmacodynamic factors are substantial to study. Among such factors, GIT absorption is the key factor in new drug development affecting the efficacy as well as safety of the drug. Different protocols have now been developed for the usage of in vitro also the in vivo as well as in situ methods in drug absorption determination. In this article, different mechanisms like passive diffusion, pore transport, ionic-mediated transport, endocytosis and other mechanisms involved in drug absorption will be explained. Moreover, different factors i.e. physico-chemical, pharmaceutical and physiological factors that affect drug absorption have been summarized as they play a significant role in the research studies for new drug development. Different absorption determining methods are also discussed.

    Absorption, Gastro-Intestinal Tract, Transport, Bioavailability, Drug Dissolution, Diffusion, Drug Stability

    (1) Rabia Mazhar
    Undergraduate Students, Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan.
    (2) Fariah Qaiser
    Undergraduate Students, Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan.
    (3) Sana Ali Zahra
    Undergraduate Students, Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan.
    (4) Syeda Komal Fatima
    Undergraduate Students, Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan.
    (5) Imran Khan
    Associate Professor, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Lahore, Punjab, Pakistan.
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Cite this article

APA

    APA : Mazhar, R., Qaiser, F., & Zahra, S. A. (2017). A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs.. Global Drug Design & Development Review, II(I), 18-33. https://doi.org/10.31703/gdddr.2017(II-I).03

CHICAGO

    CHICAGO : Mazhar, Rabia, Fariah Qaiser, and Sana Ali Zahra. 2017. "A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs.." Global Drug Design & Development Review, II (I): 18-33 doi: 10.31703/gdddr.2017(II-I).03

HARVARD

    HARVARD : MAZHAR, R., QAISER, F. & ZAHRA, S. A. 2017. A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs.. Global Drug Design & Development Review, II, 18-33.

MHRA

    MHRA : Mazhar, Rabia, Fariah Qaiser, and Sana Ali Zahra. 2017. "A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs.." Global Drug Design & Development Review, II: 18-33

MLA

    MLA : Mazhar, Rabia, Fariah Qaiser, and Sana Ali Zahra. "A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs.." Global Drug Design & Development Review, II.I (2017): 18-33 Print.

OXFORD

    OXFORD : Mazhar, Rabia, Qaiser, Fariah, and Zahra, Sana Ali (2017), "A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs.", Global Drug Design & Development Review, II (I), 18-33

TURABIAN

    TURABIAN : Mazhar, Rabia, Fariah Qaiser, and Sana Ali Zahra. "A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs.." Global Drug Design & Development Review II, no. I (2017): 18-33. https://doi.org/10.31703/gdddr.2017(II-I).03