About Us

 

A Literature Review of the Physicochemical, Physiological and Pharmaceutical Considerations in GIT Absorption of Drugs.

Views (423)
Downloads (0)


Abstract

Oral route of drug administration is the most common among all routes and hence their pharmacokinetic and pharmacodynamic factors are substantial to study. Among such factors, GIT absorption is the key factor in new drug development affecting the efficacy as well as safety of the drug. Different protocols have now been developed for the usage of in vitro also the in vivo as well as in situ methods in drug absorption determination. In this article, different mechanisms like passive diffusion, pore transport, ionic-mediated transport, endocytosis and other mechanisms involved in drug absorption will be explained. Moreover, different factors i.e. physico-chemical, pharmaceutical and physiological factors that affect drug absorption have been summarized as they play a significant role in the research studies for new drug development. Different absorption determining methods are also discussed.

Authors

1-Rabia Mazhar
Undergraduate Students, Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan.

2-Fariah Qaiser
Undergraduate Students, Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan.

3-Sana Ali Zahra
Undergraduate Students, Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan.

4-Syeda Komal Fatima
Undergraduate Students, Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan.

5-Imran Khan
Associate Professor, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore Campus, Lahore, Punjab, Pakistan.

Keywords

Absorption, Gastro-Intestinal Tract, Transport, Bioavailability, Drug Dissolution, Diffusion, Drug Stability

DOI Number

10.31703/gdddr.2017(II-I).03


Page Nos

18-33

Volume & Issue

II - I

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Published: Dec 2017

Citation Formats

ABNT   APA   BibTex   MLA   Oxford   Harvard   Chicago   Turabian   AAA   MHRA


Share Article

Google Scholar

Google Scholar

Why Choose Us

Quality of research
We are committed to publish research papers of very good quality so as to improve the impact of our publications on researchers.
Trusted Peer Review
Your article gets the most trustworthy reviews from the top professionals of the field.
Dedicated Team of Editors
We have a very well versed and qualified team of professional editors to publish your research and guide you through out the process.
Global Audience
We have the most comprehensive marketing strategy for sharing your research across the globe.
Multiple Archives
We are committed to preserve our valuable research so we submit it to multiple international archives.
Member of Crossref
Unique identifier is assigned to each article published which improves your discoverability.

Volumes

5

Authors

75

Issue

5

Articles

25