02 Pages : 9-18
http://dx.doi.org/10.31703/gdddr.2016(I-I).02 10.31703/gdddr.2016(I-I).02 Published : Dec 2016Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing
Pharmacokinetic modeling helps to estimate the ADME parameters of all the natural and synthetic drug substances in humans and animals. There are two types of approaches for predicting the kinetic processes inside the body i.e., model approach and model independent approach. Model approach is further divided into compartmental and physiological models and model independent approach consists of non-compartmental models. Compartmental modeling is the most widely used approach. It visually shows the rate processes of drug deposition and also predict the drug concentration time graph. Compartmental model consists of catenary and mammillary models. Mammillary models can either be one compartment, multi compartment or two compartments. The physiologically based pharmacokinetic models consists of compartments that correlates with various body tissues, connected by blood circulatory system. Another name for noncompartmental analysis is model-independent approach that means it does not require any compartment model.
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Pharmacokinetic, Models, Compartments, Parameters, Drug, Concentration
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(1) Duaa Aslam Chaudhry
Undergraduate Students (Final year), Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
(2) Urooj Fatima
Undergraduate Students (Final year), Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
(3) Kainat Waqar
Undergraduate Students (Final year), Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
(4) Mubashar Rehman
Assistant Professor, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
- Ahmed, T. A. (2015). Pharmacokinetics of Drugs Following IV Bolus, IV Infusion, and Oral Administration. Basic Pharmacokinetic Concepts and Some Clinical Applications https://doi.org/10.5772/61573
- Alavijeh, M. S., Chishty, M., Qaiser, M. Z., & Palmer, A. M. (2005). Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery. NeuroRX, 2(4), 554-571. https://doi.org/10.1602/neurorx.2.4.554
- Brown, R. P., Delp, M. D., Lindstedt, S. L., Rhomberg, L. R., & Beliles, R. P. (1997). Physiological Parameter Values for Physiologically Based Pharmacokinetic Models. Toxicology and Industrial Health, 13(4), 407-484. https://doi.org/10.1177/0748233797013004 01
- Carlander, U., Li, D., Jolliet, O., Emond, C., & Johanson, G. (2016). Toward a general physiologically based pharmacokinetic model for intravenously injected nanoparticles. International Journal of Nanomedicine, 625. https://doi.org/10.2147/ijn.s94370
- Denti, P., Mirochnick, M., & Cressey, T. R. (n.d.). MODULE 2: PHARMACOKINETIC MODELLING ©Courtesy of Photoshare 38. Retrieved from website: https://www.who.int/hiv/pub/2.pdf
- DiStefano, J. J., & Landaw, E. M. (1984). Multiexponential, multicompartmental, and noncompartmental modeling. I. Methodological limitations and physiological interpretations. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 246(5), R651-R664. https://doi.org/10.1152/ajpregu.1984.246.5.r6 51
- Dvorchik, B. H., & Vesell, E. S. (1976). Pharmacokinetic interpretation of data gathered during therapeutic drug monitoring. Clinical Chemistry, 22(6), 868-878. https://doi.org/10.1093/clinchem/22.6.868
- Holz, M. (2001). Compartment modeling. Advanced Drug Delivery Reviews, 48(2-3), 249-264. https://doi.org/10.1016/s0169-409x(01)00118- 1
- Jones, H. M., Parrott, N., Jorga, K., & Lave, T. (2006). A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics. Clinical Pharmacokinetics, 45(5), 511-542. https://doi.org/10.2165/00003088- 200645050-00006
- ones, H., & Rowland-Yeo, K. (2013). Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development. CPT: Pharmacometrics & Systems Pharmacology, 2(8), e63. https://doi.org/10.1038/psp.2013.41
- ok-Yong, S., & Lawrence, L. (2015). Drug Distribution and Drug Elimination. Basic Pharmacokinetic Concepts and Some Clinical Applications. https://doi.org/10.5772/59929
- MENGE, M., ROSE, M., BOHLAND, C., ZSCHIESCHE, E., KILP, S., METZ, W., ... NÜRNBERGER, M. (2011). Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle). Journal of Veterinary Pharmacology and Therapeutics, 35(6), 550-559. https://doi.org/10.1111/j.1365- 2885.2011.01349.x
- Nestorov, I. A. (1998). Lumping of whole-body physiologically based pharmacokinetic models. Journal of Pharmacokinetics and Pharmacodynamics, 26(1), 21-46. https://doi.org/10.1023/a:1023272707390
- Popović, J. K., Atanacković, M. T., Pilipović, A. S., Rapaić, M. R., Pilipović, S., & Atanacković, T. M. (2010). A new approach to the compartmental analysis in pharmacokinetics: fractional time evolution of diclofenac. Journal of Pharmacokinetics and Pharmacodynamics, 37(2), 119-134. https://doi.org/10.1007/s10928-009-9147-3
- Prabu, S. L., Suriyaprakash, T. N. K., Ruckmani, K., & Thirumurugan, R. (2015). Biopharmaceutics and Pharmacokinetics. Basic Pharmacokinetic Concepts and Some Clinical Applications. https://doi.org/10.5772/61160
- Reddy, M. B., Iii, H. J. C., Lave, T., & Andersen, M. E. (2013). Physiologically Based Pharmacokinetic Modeling: A Tool for Understanding ADMET Properties and Extrapolating to Human. New Insights into Toxicity and Drug Testing. https://doi.org/10.5772/54965
- Rowland, M., Peck, C., & Tucker, G. (2011). Physiologically Based Pharmacokinetics in Drug Development and Regulatory Science. Annual Review of Pharmacology and Toxicology, 51(1), 45-73. https://doi.org/10.1146/annurev-pharmtox- 010510-100540
- Schlender, J.-F., Meyer, M., Thelen, K., Krauss, M., Willmann, S., Eissing, T., & Jaehde, U. (2016). Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals. Clinical Pharmacokinetics, 55(12), 1573-1589. https://doi.org/10.1007/s40262- 016-0422-3
- Shuenn-Tsong Young, & Kuang-Ning Hsiao. (1994). A pharmacokinetic model to study administration of intravenous anaesthetic agents. IEEE Engineering in Medicine and Biology Magazine, 13(2), 263-268. https://doi.org/10.1109/51.281687
- Yamaoka, K., Nakagawa, T., & Uno, T. (1978). Statistical moments in pharmacokinetics. Journal of Pharmacokinetics and Biopharmaceutics, 6(6), 547-558. https://doi.org/10.1007/bf01062109
Cite this article
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APA : Chaudhry, D. A., Fatima, U., & Waqar, K. (2016). Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing. Global Drug Design & Development Review, I(I), 9-18. https://doi.org/10.31703/gdddr.2016(I-I).02
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CHICAGO : Chaudhry, Duaa Aslam, Urooj Fatima, and Kainat Waqar. 2016. "Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing." Global Drug Design & Development Review, I (I): 9-18 doi: 10.31703/gdddr.2016(I-I).02
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HARVARD : CHAUDHRY, D. A., FATIMA, U. & WAQAR, K. 2016. Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing. Global Drug Design & Development Review, I, 9-18.
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MHRA : Chaudhry, Duaa Aslam, Urooj Fatima, and Kainat Waqar. 2016. "Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing." Global Drug Design & Development Review, I: 9-18
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MLA : Chaudhry, Duaa Aslam, Urooj Fatima, and Kainat Waqar. "Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing." Global Drug Design & Development Review, I.I (2016): 9-18 Print.
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OXFORD : Chaudhry, Duaa Aslam, Fatima, Urooj, and Waqar, Kainat (2016), "Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing", Global Drug Design & Development Review, I (I), 9-18
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TURABIAN : Chaudhry, Duaa Aslam, Urooj Fatima, and Kainat Waqar. "Pharmacokinetic Modeling Concepts: Compartmental and Non-compartmental approach for Drug Designing." Global Drug Design & Development Review I, no. I (2016): 9-18. https://doi.org/10.31703/gdddr.2016(I-I).02