A Comprehensive Insight on Pharmacokinetics
Pharmacokinetics can be defined as what the body does to a drug. The basic parameters of pharmacokinetics are discussed here including absorption, distribution, metabolism, and excretion. Characteristics and pathways taken by these drugs are determined by these parameters. The mechanism followed by these parameters are also discussed. Furthermore, the factors affecting these parameters including physicochemical factors, physical factors and pharmaceutical factors are also explored. Different routes of drug absorption and main barriers to drug distribution are also explained. The pharmacokinetic values namely acid dissociation constant, bioavailability and solubility are briefly explained. There is a detailed insight into the pathways of metabolism (Phase I and II reactions) and excretion.
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Pharmacokinetics, Absorption, Distribution, Metabolism
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(1) Urooj Naseem
Undergraduate Students (Final year), Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
(2) Fatima Iqbal
Undergraduate Students (Final year), Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
(3) Gul Shahnaz
Chairperson, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
- Eason, C. T., Bonner, F. W., & Parke, D. V. (1990). The importance of pharmacokinetic and receptor studies in drug safety evaluation. Regulatory Toxicology and Pharmacology, 11(3), 288-307.
- Foti, R. S. et al (2015).
- Danhof, M. (2015). Kinetics of drug action in disease states: towards physiology-based pharmacodynamic (PBPD) models. J. Pharmacokinet. Pharmacodyn. 42, 447- 462
- Jones, H. M., Mayawala, K. & Poulin, P. (2013). Dose selection based on physiologically based pharmacokinetic (PBPK) approaches. AAPS J. 15, 377- 387.
- Morgan, P. et al (2012). Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving phase II survival. Drug Discov. Today. 17, 419- 424.
- Rowland M, Benet, L. Z., & Graham, G. G. (1973). Clearance concepts in pharmacokinetics. J Pharmacokinet Biopharm. 1(2):123-36.
- Rowland, M., Lesko, L. J. & Rostami-Hodjegan. (2015). A. Physiologically based pharmacokinetics is impacting drug development and regulatory decision making. CPT Pharmacometrics Syst. Pharmacol. 4, 313-315.
Cite this article
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APA : Naseem, U., Iqbal, F., & Shahnaz, G. (2016). A Comprehensive Insight on Pharmacokinetics. Global Drug Design & Development Review, I(I), 27-37. https://doi.org/10.31703/gdddr.2016(I-I).04
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CHICAGO : Naseem, Urooj, Fatima Iqbal, and Gul Shahnaz. 2016. "A Comprehensive Insight on Pharmacokinetics." Global Drug Design & Development Review, I (I): 27-37 doi: 10.31703/gdddr.2016(I-I).04
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HARVARD : NASEEM, U., IQBAL, F. & SHAHNAZ, G. 2016. A Comprehensive Insight on Pharmacokinetics. Global Drug Design & Development Review, I, 27-37.
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MHRA : Naseem, Urooj, Fatima Iqbal, and Gul Shahnaz. 2016. "A Comprehensive Insight on Pharmacokinetics." Global Drug Design & Development Review, I: 27-37
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MLA : Naseem, Urooj, Fatima Iqbal, and Gul Shahnaz. "A Comprehensive Insight on Pharmacokinetics." Global Drug Design & Development Review, I.I (2016): 27-37 Print.
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OXFORD : Naseem, Urooj, Iqbal, Fatima, and Shahnaz, Gul (2016), "A Comprehensive Insight on Pharmacokinetics", Global Drug Design & Development Review, I (I), 27-37
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TURABIAN : Naseem, Urooj, Fatima Iqbal, and Gul Shahnaz. "A Comprehensive Insight on Pharmacokinetics." Global Drug Design & Development Review I, no. I (2016): 27-37. https://doi.org/10.31703/gdddr.2016(I-I).04