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HCV GENOTYPES DISTRIBUTION AMONG HCV PATIENTS WITH BIOCHEMICAL MARKERS IN DISTRICT MARDAN

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http://dx.doi.org/10.31703/gdddr.2022(VII-III).01      10.31703/gdddr.2022(VII-III).01      Published : Sep 2022

HCV Genotypes Distribution among HCV Patients with Biochemical markers in District Mardan

Abstract

    Hepatitis C causes chronic liver disease, cirrhosis, and hepatocellular cancer, and its genotypes vary widely among countries. This study aimed to determine HCV patients' genotype distribution and biochemical indicators. Blood samples from enrolled HCV-positive cases were processed and viral RNA was extracted using the "RNA extraction Qiagene kit" to genotype and quantify viral load using Real Time polymerase chain reaction (Rotor Gene Q-PCR equipment).Analysis was performed by SPSS with p-value < 0.05. Results showed that 198 (91.66%) of 216 patients were 3a genotyped and had higher Alanine aminotransferase (ALT; 39-85%). Genotype 3a dominates in Mardan and nearby areas. Infected patients with genotype-3a had a greater pre-treatment HCV viral load than those with genotypes 1a, 1b, and 5a, although other genotypes had higher biochemical markers (P<0.05).

    Biochemical Markers, Genotype, Hepatitis C Virus, Prevalence, Viral Load

    (1) Khalida Kousar
    Assistant Professor, Department of Microbiology, Bacha Khan Medical College, Mardan, KP, Pakistan.
    (2) Hayat Ur Rehman
    Professor, Department of Paediatric Surgery, Qazi Husain Ahmad Medical Complex, Nowshera, KP, Pakistan.
    (3) Abida Yasmeen
    Assistant Professor, Department of Pharmacology, Khyber Girls Medical College, Peshawar, KP, Pakistan.
    (4) Muhammad Fayaz
    Department of Paediatric Surgery, Qazi Husain Ahmad Medical Complex, Nowshera, KP, Pakistan.
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Cite this article

APA

    APA : Kousar, K., Rehman, H. U., & Yasmeen, A. (2022). HCV Genotypes Distribution among HCV Patients with Biochemical markers in District Mardan. Global Drug Design & Development Review, VII(III), 1-7. https://doi.org/10.31703/gdddr.2022(VII-III).01

CHICAGO

    CHICAGO : Kousar, Khalida, Hayat Ur Rehman, and Abida Yasmeen. 2022. "HCV Genotypes Distribution among HCV Patients with Biochemical markers in District Mardan." Global Drug Design & Development Review, VII (III): 1-7 doi: 10.31703/gdddr.2022(VII-III).01

HARVARD

    HARVARD : KOUSAR, K., REHMAN, H. U. & YASMEEN, A. 2022. HCV Genotypes Distribution among HCV Patients with Biochemical markers in District Mardan. Global Drug Design & Development Review, VII, 1-7.

MHRA

    MHRA : Kousar, Khalida, Hayat Ur Rehman, and Abida Yasmeen. 2022. "HCV Genotypes Distribution among HCV Patients with Biochemical markers in District Mardan." Global Drug Design & Development Review, VII: 1-7

MLA

    MLA : Kousar, Khalida, Hayat Ur Rehman, and Abida Yasmeen. "HCV Genotypes Distribution among HCV Patients with Biochemical markers in District Mardan." Global Drug Design & Development Review, VII.III (2022): 1-7 Print.

OXFORD

    OXFORD : Kousar, Khalida, Rehman, Hayat Ur, and Yasmeen, Abida (2022), "HCV Genotypes Distribution among HCV Patients with Biochemical markers in District Mardan", Global Drug Design & Development Review, VII (III), 1-7

TURABIAN

    TURABIAN : Kousar, Khalida, Hayat Ur Rehman, and Abida Yasmeen. "HCV Genotypes Distribution among HCV Patients with Biochemical markers in District Mardan." Global Drug Design & Development Review VII, no. III (2022): 1-7. https://doi.org/10.31703/gdddr.2022(VII-III).01