Antibiotics are chemical substances produced by microorganisms. This study aims to find the prescribing practices of broad-spectrum antibiotics in tertiary care hospitals. It is a descriptive observational chart review of patients who have been prescribed broad-spectrum antibiotics in Lady Reading Hospital, Peshawar and data is collected using a standardized chart obtained from the World Health Organization and then analyzed using software such as Microsoft Excel and Statistical software. The results suggested that the frequency and percentage of the broad spectrum antibiotics are high and most broad-spectrum antibiotics prescribed are empirical. Furthermore, the study suggests that educational programs such as antibiotics stewardship programs should be utilized to educate the prescriber in the hospital, which aims to reduce the risks and various complications associated with the use of broad-spectrum antibiotics. Culture samples are required before administration of antimicrobials. Frequent reassessment of the patient's condition and antimicrobial therapy may be indicated.