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http://dx.doi.org/10.31703/gdddr.2023(VIII-I).01 10.31703/gdddr.2023(VIII-I).01 Published : Mar 2023Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements
Introduction: Diabetics lack potassium and magnesium. (Mg). Hypokalemia and hypomagnesemia cause vasoconstriction and glucose breakdown, so all hypomagnesemia diabetics should take K and Mg daily to prevent diabetic arterial disease. Methodology: 80 types 1 diabetes (T1-DM) patients were analyzed for parameters like K, Mg, Serum, Lipids, and HBA1c. After giving 1.7mg/dL blood Mg patients, 300mg Mg oxide daily for 3 months, the parameters were re-examined. 40 insulin-dependent diabetic men and women averaged 16.79 ± 4.00 years, Mg 2.94.38/dL. 30.3% had hypomagnesemia. Blood magnesium levels are inversely associated with age, diabetes length (P value 0.002) and other parameters and are favourably correlated with mean corpuscular volume, HDL, and platelet counts. Mg supplementation substantially lowered HBA1c. HBA1c started at 09.22%1.98%. Oral K and Mg tablets for three months lower it to 6.77%1.53%. (P0.003). it also lowered LDL, blood lipids, and total cholesterol in hypomagnesemia diabetics. Conclusion: Oral Mg intake in T1-DM patients improves glucose control, atherogenic lipid proportion, and therapeutic lipid component.
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Vitamin D, Calciferol, 25(OH)D, Blood Pressure, Diabetes Mellitus
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(1) Muhammad Bilal Khattak
Associate Professor, Department of Medicine, Khyber Girls Medical College, Peshawar, KP, Pakistan.
(2) Farid Ullah Shah
Associate Professor, Department of Biochemistry, Pak International Medical College, Peshawar, KP, Pakistan.
(3) Mehreen Ismail
Department of Biochemistry, Khyber Medical University, Peshawar, KP, Pakistan.
(4) Javaid Hassan
Assistant Professor, Department of Physiology, Muhammad College of Medicine, Yasin Abad, Budni Road, Peshawar, KP, Pakistan.
(5) Sara Mariyum
Associate Professor, Department of Biochemistry, Swat Medical College, Swat, KP, Pakistan.
(6) Muhammad Kashif Shahid Khan
MPhil Scholar, Department of Biochemistry, Khyber Girls Medical College, Peshawar, KP, Pakistan.
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Cite this article
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APA : Khattak, M. B., Shah, F. U., & Ismail, M. (2023). Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements. Global Drug Design & Development Review, VIII(I), 1-7. https://doi.org/10.31703/gdddr.2023(VIII-I).01
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CHICAGO : Khattak, Muhammad Bilal, Farid Ullah Shah, and Mehreen Ismail. 2023. "Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements." Global Drug Design & Development Review, VIII (I): 1-7 doi: 10.31703/gdddr.2023(VIII-I).01
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HARVARD : KHATTAK, M. B., SHAH, F. U. & ISMAIL, M. 2023. Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements. Global Drug Design & Development Review, VIII, 1-7.
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MHRA : Khattak, Muhammad Bilal, Farid Ullah Shah, and Mehreen Ismail. 2023. "Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements." Global Drug Design & Development Review, VIII: 1-7
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MLA : Khattak, Muhammad Bilal, Farid Ullah Shah, and Mehreen Ismail. "Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements." Global Drug Design & Development Review, VIII.I (2023): 1-7 Print.
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OXFORD : Khattak, Muhammad Bilal, Shah, Farid Ullah, and Ismail, Mehreen (2023), "Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements", Global Drug Design & Development Review, VIII (I), 1-7
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TURABIAN : Khattak, Muhammad Bilal, Farid Ullah Shah, and Mehreen Ismail. "Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements." Global Drug Design & Development Review VIII, no. I (2023): 1-7. https://doi.org/10.31703/gdddr.2023(VIII-I).01