ARTICLE

ORAL ADMINISTRATION OF MAGNESIUM HYDROXIDE TO SUBJECTS WITH INSULINDEPENDENT DIABETES MELLITUS EFFECTS ON MAGNESIUM AND POTASSIUM LEVELS AND ON INSULIN REQUIREMENTS

  1. HOME
  2. ARTICLE

01 Pages : 1-7

http://dx.doi.org/10.31703/gdddr.2023(VIII-I).01      10.31703/gdddr.2023(VIII-I).01      Published : Mar 2023

Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements

Abstract

    Introduction: Diabetics lack potassium and magnesium. (Mg). Hypokalemia and hypomagnesemia cause vasoconstriction and glucose breakdown, so all hypomagnesemia diabetics should take K and Mg daily to prevent diabetic arterial disease. Methodology: 80 types 1 diabetes (T1-DM) patients were analyzed for parameters like K, Mg, Serum, Lipids, and HBA1c. After giving 1.7mg/dL blood Mg patients, 300mg Mg oxide daily for 3 months, the parameters were re-examined. 40 insulin-dependent diabetic men and women averaged 16.79 ± 4.00 years, Mg 2.94.38/dL. 30.3% had hypomagnesemia. Blood magnesium levels are inversely associated with age, diabetes length (P value 0.002) and other parameters and are favourably correlated with mean corpuscular volume, HDL, and platelet counts. Mg supplementation substantially lowered HBA1c. HBA1c started at 09.22%1.98%. Oral K and Mg tablets for three months lower it to 6.77%1.53%. (P0.003). it also lowered LDL, blood lipids, and total cholesterol in hypomagnesemia diabetics. Conclusion: Oral Mg intake in T1-DM patients improves glucose control, atherogenic lipid proportion, and therapeutic lipid component.

    Vitamin D, Calciferol, 25(OH)D, Blood Pressure, Diabetes Mellitus

    (1) Muhammad Bilal Khattak
    Associate Professor, Department of Medicine, Khyber Girls Medical College, Peshawar, KP, Pakistan.
    (2) Farid Ullah Shah
    Associate Professor, Department of Biochemistry, Pak International Medical College, Peshawar, KP, Pakistan.
    (3) Mehreen Ismail
    Department of Biochemistry, Khyber Medical University, Peshawar, KP, Pakistan.
    (4) Javaid Hassan
    Assistant Professor, Department of Physiology, Muhammad College of Medicine, Yasin Abad, Budni Road, Peshawar, KP, Pakistan.
    (5) Sara Mariyum
    Associate Professor, Department of Biochemistry, Swat Medical College, Swat, KP, Pakistan.
    (6) Muhammad Kashif Shahid Khan
    MPhil Scholar, Department of Biochemistry, Khyber Girls Medical College, Peshawar, KP, Pakistan.
Fulltext PDF

References

  • Ansari, P., Azam, S., Hannan, J., Flatt, P. R., & Wahab, Y. H. A. (2020). The anti- hyperglycaemic activity of H. rosa-sinensis leaves is partly mediated by the inhibition of carbohydrate digestion and absorption, and enhancement of insulin secretion. Journal of Ethnopharmacology.253, 112647. https://doi.org/10.1016/j.jep.2020.112647
  • Cotero, V., Graf, J., Miwa, H., Hirschstein, Z., Qanud, K., & Huerta, T. S, (2022). Stimulation of the hepatoportal nerve plexus with focused ultrasound restores glucose homoeostasis in diabetic mice, rats and swine. Nature Biomedical Engineering. 6(6), 683- 705. https://doi.org/10.1038/s41551-022-00870-w
  • Doyno, C., Sobieraj, D. M., & Baker, W. L. (2021). Toxicity of chloroquine and hydroxychloroquine following therapeutic use or overdose. Clinical Toxicology. 59(1), 12-23. https://doi.org/10.1080/15563650.2020.1817479
  • Ediga, M. G., Annapureddy, S., Salikineedy, K., & Nimgampalle, M. (2023). Aspartame consumption causes cognitive impairment in streptozotocin-induced diabetic Wistar rats. Biologia. 1-15. https://doi.org/10.1007/s11756-023-01363-0
  • El-Moataaz, S., Ismael, H., & Aborhyem, S. (2019). Assessment of the chemical composition of Spirulina platensis and its effect on fasting blood glucose and lipid profile in diabetic Rats. Journal of High Institute of Public Health. 49(3):199-211. https://doi.org/10.21608/jhiph.2019.64463
  • Gadoa, Z. A., Moustafa, A. H., Rayes, S. M., Arisha, A. A., & Mansour, M. F. (2022). Zinc Oxide Nanoparticles and Synthesized Pyrazolopyrimidine Alleviate Diabetic Effects in Rats Induced by Type II Diabetes. ACS omega. 7(41), 36865-72. https://doi.org/10.1021/acsomega.2c05638
  • Garg, R., Katekar, R., Parwez, S., Agarwal, A., Sahu, S., & Dadge, S. (2023). Pancreastatin inhibitor PSTi8 ameliorates streptozotocin- induced diabetes by suppressing hepatic glucose production. European Journal of Pharmacology. 944, 175559. https://doi.org/10.1016/j.ejphar.2023.175559
  • Jiang, N., & Zhang, Y. (2022). Antidiabetic effects of nerolidol through promoting insulin receptor signalling in high-fat diet and low dose streptozotocin-induced type 2 diabetic rats. Human & Experimental Toxicology. 41, 09603271221126487. https://doi.org/10.1177/09603271221126487
  • Labban, L., & Thallaj, N. (2019). The Effect of Magnesium Supplementation on Hba1c Level and Lipid Profile among Type 2 Diabetics. Acta Scientific Nutritional Health. 3, 07-12. https://doi.org/10.1007/s12011-020-02209-5
  • Liu, M., & Dudley, J. S. C. (2020). Magnesium, oxidative stress, inflammation, and cardiovascular disease. Antioxidants. 9(10), 907. https://doi.org/10.3390/antiox9100907
  • Mehta, R. J., Gastaldelli, A., Balas, B., Ricotti, A., DeFronzo, R. A., & Tripathy, D. (2019). Mechanism of action of inhaled insulin on whole-body glucose metabolism in subjects with type 2 diabetes mellitus. International journal of molecular sciences. 20(17), 4230. https://doi.org/10.3390/ijms20174230
  • Mohammed, S. Y., Ibrahim, A., Bashir, M., Idi, A., & Sule, Z. D. (2022). Combined Effect of Sorghum Bicolor Formulated Diet and Glibenclamide on Some Biochemical Changes in Alloxan-Induced Diabetic Rats. Nigerian Journal of Biochemistry and Molecular Biology. 37(3), 212-21. https://doi.org/10.2659/njbmb.2022.63
  • Olofinsan, K. A., Salau, V. F., Erukainure, O. L., & Islam, M. S. (2023). Senna petersiana (Bolle) leaf extract modulates glycemic homeostasis and improves dysregulated enzyme activities in fructose-fed streptozotocin-induced diabetic rats. Journal of Ethnopharmacology. 303, 115998. https://doi.org/10.1016/j.jep.2022.115998
  • Pamela, O., Francis, A., Celestine, A., Ifeoma, A., Choice, N., & Pamela, A. (2019). The effect of aqueous leaf extract of Adansonia digitata (baobab) on diabetes mellitus and the anterior pituitary of adult male wistar rats. Journal of Diabetes and Endocrinology. 10(3), 18-29. https://doi.org/10.5897/JDE2019.0131
  • Rizk, J., Quan, D., Gabardi, S., Rizk, Y., & Kalantar-Zadeh, K. (2021). Novel approaches to the management of hyperkalaemia in kidney transplantation. Current opinion in nephrology and hypertension. 30(1), 27-37. https://doi.org/10.1097/MNH.0000000000000657
  • Subbiah, A. J., Kavimani, M., Ramadoss, M., Rao, M. R. K., & Prabhu, K. (2021). Effect of katakakhadiradi kashayam on lipid profile and pancreatic damage in type II diabetes mellitus. J Pharm Res Int. 33(28B), 135-41. https://doi.org/10.9734/jpri/2021/v33i28B31547
  • Tegegne, B. A., Mekuria, A. B., & Birru, E. M. (2022). Evaluation of anti-diabetic and anti- hyperlipidemic activities of hydro-alcoholic crude extract of the shoot tips of Crinum abyssinicum hochst. Ex A. Rich (amaryllidaceae) in mice. Journal of Experimental Pharmacology. 27-41. https://doi.org/10.2147/JEP.S335650
  • Tobar, N., Rocha, G. Z., Santos, A., Guadagnini, D., Assalin, H. B., & Camargo, J. A. (2023). Metformin acts in the gut and induces gut- liver crosstalk. Proceedings of the National Academy of Sciences. 120(4), e2211933120. https://doi.org.10.1073/pnas.2211933120.
  • Vargas-Uricoechea, H. (2022). Current State and Principles of Basal Insulin Therapy in Type 2 Diabetes. Journal of Clinical Medicine Research. 14(1), 8. https://doi.org/10.14740/jocmr4660

Cite this article

APA

    APA : Khattak, M. B., Shah, F. U., & Ismail, M. (2023). Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements. Global Drug Design & Development Review, VIII(I), 1-7. https://doi.org/10.31703/gdddr.2023(VIII-I).01

CHICAGO

    CHICAGO : Khattak, Muhammad Bilal, Farid Ullah Shah, and Mehreen Ismail. 2023. "Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements." Global Drug Design & Development Review, VIII (I): 1-7 doi: 10.31703/gdddr.2023(VIII-I).01

HARVARD

    HARVARD : KHATTAK, M. B., SHAH, F. U. & ISMAIL, M. 2023. Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements. Global Drug Design & Development Review, VIII, 1-7.

MHRA

    MHRA : Khattak, Muhammad Bilal, Farid Ullah Shah, and Mehreen Ismail. 2023. "Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements." Global Drug Design & Development Review, VIII: 1-7

MLA

    MLA : Khattak, Muhammad Bilal, Farid Ullah Shah, and Mehreen Ismail. "Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements." Global Drug Design & Development Review, VIII.I (2023): 1-7 Print.

OXFORD

    OXFORD : Khattak, Muhammad Bilal, Shah, Farid Ullah, and Ismail, Mehreen (2023), "Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements", Global Drug Design & Development Review, VIII (I), 1-7

TURABIAN

    TURABIAN : Khattak, Muhammad Bilal, Farid Ullah Shah, and Mehreen Ismail. "Oral Administration of Magnesium Hydroxide to Subjects with Insulin-dependent Diabetes Mellitus: Effects on Magnesium and Potassium Levels and on Insulin Requirements." Global Drug Design & Development Review VIII, no. I (2023): 1-7. https://doi.org/10.31703/gdddr.2023(VIII-I).01