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BIOTECHNOLOGICAL ADVANCEMENTS IN STREPTOKINASE PRODUCTION

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05 Pages : 46-60

http://dx.doi.org/10.31703/gdddr.2023(VIII-IV).05      10.31703/gdddr.2023(VIII-IV).05      Published : Dec 2023

Biotechnological Advancements in Streptokinase Production

Abstract

    This article offers a deep analysis of activating streptokinase which looks into the biotechnological challenges and future perspectives. One of the main problems associated with streptokinase is its short half-life, complex production process, and immunogenicity which hinders patients from getting a successful reperfusion. Yet, the development of biotechnology methods that would not face these drawbacks, such as the strategy of recombinant streptokinase production and enzyme engineering theories, is a promise. This paper aims to provide an overview of biotechnological breakthroughs in the production of streptokinase with a focus on discovering long-lasting formulations exhibiting less immunogenicity and in addition the economic viability and scalability of biotechnological production processes. This article also gives the comping image of known purification methods like chromatography, ultrafiltration, and I-A chromatography for the separation and purification of streptokinase. In addition, the author presents the advantage of such suitable production technologies as cell-free production systems and E. Coli system optimization, such as recombinant streptokinase synthesis in Yeast systems. Biotechnology is turning out to be a new area, having a future boom due to the rising innovation and demand that are associated with the prospects revealed by the market trends.

    Streptokinase, Enzyme Engineering, Recombinant Streptokinase, Streptokinase Gene Cloning

    (1) Muhammad Asim
    Graduate Scholar, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Faiza Mushtaq
    Graduate Scholar, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Minahil Qadeer
    Graduate Scholar, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (4) Sidra Sarwar
    Graduate Scholar, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (5) Areej Ali
    Graduate Scholar, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (6) Maryam Ahmad
    Graduate Scholar, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
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Cite this article

APA

CHICAGO

    CHICAGO : Asim, Muhammad, Faiza Mushtaq, and Minahil Qadeer. 2023. "Biotechnological Advancements in Streptokinase Production." Global Drug Design & Development Review, VIII (IV): 46-60 doi: 10.31703/gdddr.2023(VIII-IV).05

HARVARD

    HARVARD : ASIM, M., MUSHTAQ, F. & QADEER, M. 2023. Biotechnological Advancements in Streptokinase Production. Global Drug Design & Development Review, VIII, 46-60.

MHRA

    MHRA : Asim, Muhammad, Faiza Mushtaq, and Minahil Qadeer. 2023. "Biotechnological Advancements in Streptokinase Production." Global Drug Design & Development Review, VIII: 46-60

MLA

    MLA : Asim, Muhammad, Faiza Mushtaq, and Minahil Qadeer. "Biotechnological Advancements in Streptokinase Production." Global Drug Design & Development Review, VIII.IV (2023): 46-60 Print.

OXFORD

    OXFORD : Asim, Muhammad, Mushtaq, Faiza, and Qadeer, Minahil (2023), "Biotechnological Advancements in Streptokinase Production", Global Drug Design & Development Review, VIII (IV), 46-60

TURABIAN

    TURABIAN : Asim, Muhammad, Faiza Mushtaq, and Minahil Qadeer. "Biotechnological Advancements in Streptokinase Production." Global Drug Design & Development Review VIII, no. IV (2023): 46-60. https://doi.org/10.31703/gdddr.2023(VIII-IV).05