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ROLE OF PROBIOTICS AND MICROBIOTA IN COVID19

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http://dx.doi.org/10.31703/gdddr.2021(VI-III).01      10.31703/gdddr.2021(VI-III).01      Published : Sep 2021

Role Of Probiotics And Microbiota In Covid-19

Abstract

    Identifying the mechanism of Covid-19 illness and its development can bring the discovery of new objectives for prevention or therapy. This might be accomplished by preventing viral entrance and replication, or just by suppressing the immune reaction elicited by the disease. Probiotics are described as"beneficial microorganisms that impose a health benefit on the host when given in suitable concentrations."There is strong scientific research to prove the capacity of probiotics in increasing human immune response,hence avoiding pathogen proliferation and lowering the occurrence and severity of diseases. We report clinical data on the usefulness of probiotic supplements to protect and cure respiratory system infections in this paper. The findings suggest that probiotics may be beneficial in lowering the likelihood of coronavirus infection. Furthermore, this domain needs to be explored to unleash the strength of probiotics and microbiotain fighting against COVID-19.

    Covid-19, Microbiota, Probiotics, SARS-COV-2

    (1) Afia Arshad
    Amna Inayat Medical College, Lahore, Punjab, Pakistan
    (2) Alia Eum
    Faculty of Pharmacy, University of Sargodha, Sargodha, Punjab, Pakistan
    (3) Ume Ruqia Tulain
    Lecturer, College of Pharmacy, University of Sargodha, Sargodha, Punjab, Pakistan.
    (4) Nadia Shamshad Malik
    Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan
    (5) Shafa Arshad
    Imran Idress College of Pharmacy, Sialkot, Punjab, Pakistan.
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References

  • Agans, R., et al., (2011). Distal gut microbiota of adolescent children is different from that of adults. FEMS Microbiol Ecol. 77(2), 404- 12.
  • Azkur, A. K., Akdis, M., Azkur, D., Sokolowska, M., van de Veen, W., Brüggen, M-C., et al. (2020 ). Immune response to SARS-CoV-2 and mechanisms of immunopathological changes in COVID-19. 75(15), 64-81.
  • Baindara, P., et al., (2021). Oral probiotics in coronavirus disease 2019: Connecting the gut-lung axis to viral pathogenesis, inflammation, secondary infection and clinical trials.
  • Barcik, W., et al., (2020). The role of lung and gut microbiota in the pathology of asthma. 52(2), 241-255.
  • Bassis, C.M., et al., (2015). Analysis of the upper respiratory tract microbiotas as the source of the lung and gastric microbiotas in healthy individuals. 6(2), 37-15.
  • Baud, D., et al., (2020). Using probiotics to flatten the curve of coronavirus disease COVID-2019 pandemic.
  • Bingula, R., et al., (2017). Desired turbulence? Gut-lung axis, immunity, and lung cancer.
  • Boursi, B., et al., (2015). Recurrent antibiotic exposure may promote cancer formation- another step in understanding the role of the human microbiota? 51(17), 2655-2664.
  • Bustamante, M., et al., (2020). Probiotics and prebiotics potential for the care of skin, female urogenital tract, and respiratory tract. 65(2), 245-264.
  • Chan, J. F.-W., et al., (2020). A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to- person transmission: a study of a family cluster. 395(10223), 514-523
  • Chen, N., et al., (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.395(10223), 507- 513.
  • Chen, Y., et al., (2021). Six-month follow-up of gut microbiota richness in patients with COVID-19.
  • Collado, M. C., et al. (2018). Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study. 32(4), 2060-72.
  • Collado, M. C., et al., (2018). Timing of food intake impacts daily rhythms of human salivary microbiota: a randomized, crossover study. 32(4), 60-72.
  • Davison, G., Kehaya, C., & A, J. A. j. O. L. M. (2016). Wyn Jones, Nutritional and physical activity interventions to improve immunity. 10(3), 152-169.
  • Dhar, D. & Mohanty, A. J. V. R., (2020). Gut microbiota and Covid-19-possible link and implications.
  • Dickson, (2016). The microbiome and critical illness. 4(1), 59-72.
  • Dickson, R., et al., (2016) Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome. Nat Microbiol.
  • Dickson, R.P., et al., (2017). Bacterial topography of the healthy human lower respiratory tract. 8(1), 2287-16.
  • Dumas, A., et al., (2018). The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases. 20(12), 12966.
  • Fagundes, C.T., et al., (2012). Transient TLR activation restores inflammatory response and ability to control pulmonary bacterial infection in germfree mice. 188(3), 1411- 1420.
  • Gill, H.S., et al., (2001). Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. 74(6), 833- 839.
  • Gu, S., et al., (2020). Alterations of the gut microbiota in patients with coronavirus disease 2019 or H1N1 influenza. 71(10), 2669-2678.
  • Guan, W.-j., et al., (2020). Clinical characteristics of coronavirus disease 2019 in China. 382(18), 1708-1720.
  • Hoffmann, M., et al., (2020). SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. 181(2), 271-280.
  • Holshue, M.L., et al., (2020). First case of 2019 novel coronavirus in the United States.
  • Holshue, M.L., et al., (2020). First case of 2019 novel coronavirus in the United States. Chen, Y., et al., (2021). Six-month follow-up of gut microbiota richness in patients with COVID-19.
  • Hu, J., et al., (2020). Probiotics, prebiotics and dietary approaches during COVID-19 pandemic.
  • Ivanov, I.I., Honda, K. J. C. h., & Microbe, (2012). Intestinal commensal microbes as immune modulators. 12(4), 496-508.
  • Jia, W., et al., (2018). Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. 15(2), 111-128.
  • Johnson, A. J., et al. (2019). Daily sampling reveals personalized diet-microbiome associations in humans. Cell Host Microbe. 25(6), 789-802.
  • Kaczmarek, J. L., Musaad S.M., & Holscher, H.D. (2017). Time of day and eating behaviours are associated with the composition and function of the human gastrointestinal microbiota. American J clin nutr. 106(5), 1220-3.
  • Kopel, J., et al., (2020). Clinical insights into the gastrointestinal manifestations of COVID- 19. 65, 1932-1939.
  • Kuang, Z., et al., (2019). The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3. 365(6460), 1428-1434.
  • Kuba, K., et al., (2005). A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. 11(8), 875-879.
  • Lahti, L., et al., (2014). Tipping elements in the human intestinal ecosystem. Nat Commun. 43-44.
  • Lee, I.-C., T.-I. & Huang, Y.-H. J. J. O .T. C. M. A. (2020). Gastrointestinal and liver manifestations in patients with COVID-19
  • Lee, P.-I., et al., (2020). Are children less susceptible to COVID-19? 53(3), 371.
  • Li, G., et al., (2020). Coronavirus infections and immune responses. 92(4), 424-432.
  • Liévin-Le Moal, V., & Servin, A. L. J. C. M. R. (2006). The front line of enteric host defense against unwelcome intrusion of harmful microorganisms: mucins, antimicrobial peptides, and microbiota. 19(2), 315-337.
  • Looft, T., and Allen, H. K. J. G. M. (2012). Collateral effects of antibiotics on mammalian gut microbiomes. 3(5), 463- 467.
  • Lu, C.-w., X.-f. Liu, & Z.-f.J.L. Jia. (2020). 2019 - nCoV transmission through the ocular surface must not be ignored. 395(10224), 39.
  • Moens, E. (2012). Veldhoen, Epithelial barrier biology: good fences make good neighbours. 135(1), 1-8.
  • Nagpal, R., et al., (2018). Gut microbiome and aging: Physiological and mechanistic insights. 4(4), 267-285.
  • Negi, S., et al., (2019). Gut microbiota regulates mincle mediated activation of lung dendritic cells to protect against Mycobacterium tuberculosis. 11-42
  • Negi, S., et al., (2019). Potential role of gut microbiota in induction and regulation of innate immune memory. 24-41.
  • Ng, S. C., & Tilg, H. J. G. COVID-19 and the gastrointestinal tract: more than meets the eye. 69(6) 973-974.
  • Organization, WHO, (2020). World Health Organization coronavirus disease (COVID- 19) dashboard.
  • Pan, L., et al., (2020). Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study.
  • Rajilić-Stojanović, M., & W, M. J. F. M. R. De Vos. (2014). The first 1000 cultured species of the human gastrointestinal microbiota. 38(5), 996-1047.
  • Rodriguez-Morales, A.J., et al., (2020). Clinical, laboratory and imaging features of COVID- 19: A systematic review and meta-analysis. 34, 101-623.
  • Rooks, M.G., & Garrett, W. S. J.N. R. I. (2016). Gut microbiota, metabolites and host immunity. 16(6), 341-352.
  • Round, J. L., & Mazmanian, (2010). Inducible Foxp3 regulatory T-cell development by a commensal bacterium of the intestinal microbiota. 107(27) 12204-12209
  • Sender, R., S. Fuchs., & R.J.P.b. Milo, (2016). Revised estimates for the number of human and bacteria cells in the body. 14(8), 1002533.
  • Shen, (2017). Diet and gut microbiota in health and disease. 117-126.
  • Shen, Z., et al., (2020 ). Genomic diversity of SARS-CoV-2 in coronavirus disease 2019 patients. Epub ahead of print 9 March 2020.
  • Sundararaman, A., et al., (2020). Role of probiotics to combat viral infections with emphasis on COVID-19. 1-16.
  • Sze, M.A., et al., (2014). Changes in the bacterial microbiota in gut, blood, and lungs following acute LPS instillation into mice lungs. 9(10), 111-228.
  • Tang, L., et al., (2020). Clinical significance of the correlation between changes in the major intestinal bacteria species and COVID-19 severity. 6(10), 1178-1184.
  • Thaiss C.A., et al., (2014).Transkingdom control of microbiota diurnal oscillations promote metabolic homeostasis. Cell. 159(3), 514-29
  • Thaiss, C.A., et al., (2016). Persistent microbiome alterations modulate the rate of post-dieting weight regain. 540(7634), 544- 551.
  • Trompette, A., et al., (2014). Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. 20(2), 159-166.
  • Valdes, A.M., et al., (2018). Role of the gut microbiota in nutrition and health.
  • Williams, N. T., & Probiotics. (2010). Am J Health Syst Pharm. 449-58
  • Wu, C., et al., (2020). The volatile and heterogenous gut microbiota shifts of COVID-19 patients over the course of a probiotics-assisted therapy.
  • Xiao, F., et al., (2020). Evidence for gastrointestinal infection of SARS-CoV-2. 158(6), 1831-1833.
  • Xie, M. (2020). Insight into 2019 novel coronavirus - An updated interim review and lessons from SARS-CoV and MERS- CoV.. 94, 119-124.
  • Xu, K. H. Cai, & Shen, Y. Management of corona virus disease-19 (COVID-19): the Zhejiang experience. J Zhejiang Univ (Med Sci). 1-12.
  • Xu, X.-W., et al., (2020). Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series.
  • Yeoh, Y.K., et al., (2021). Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. 70(4), 698-706.
  • Yeoh, Y.K., et al., (2021). Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. 70(4), 698-706.
  • Zhang, H., et al., (2020). Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process. 69(6), 1010- 1018
  • Zhang, Y.-J., et al., (2015). Impacts of gut bacteria on human health and diseases.16(4), 7493-7519.
  • Zhao, Y., et al., (2018). GPR43 mediates microbiota metabolite SCFA regulation of antimicrobial peptide expression in intestinal epithelial cells via activation of mTOR and STAT3. 11(3), 752-762.
  • Zhu, N., et al., (2020). A novel coronavirus from patients with pneumonia in China, 2019.
  • Zimmermann, P. (2020). Curtis, Coronavirus infections in children including COVID-19: an overview of the epidemiology, clinical features, diagnosis, treatment and prevention options in children. 39(5), 355.
  • Zu, Z.Y., et al., (2020). Coronavirus disease 2019 (COVID-19): a perspective from China. 296(2), 15-25.
  • Zuo, T., et al., (2020). Alterations in gut microbiota of patients with COVID-19 during time of hospitalization. 159(3), 944- 955.
  • Zuo, T., et al., (2021). Depicting SARS-CoV-2 faecal viral activity in association with gut microbiota composition in patients with COVID-19. 70(2), 276-284.

Cite this article

APA

CHICAGO

    CHICAGO : Arshad, Afia, Alia Eum, and Ume Ruqia Tulain. 2021. "Role Of Probiotics And Microbiota In Covid-19." Global Drug Design & Development Review, VI (III): 1-11 doi: 10.31703/gdddr.2021(VI-III).01

HARVARD

    HARVARD : ARSHAD, A., EUM, A. & TULAIN, U. R. 2021. Role Of Probiotics And Microbiota In Covid-19. Global Drug Design & Development Review, VI, 1-11.

MHRA

    MHRA : Arshad, Afia, Alia Eum, and Ume Ruqia Tulain. 2021. "Role Of Probiotics And Microbiota In Covid-19." Global Drug Design & Development Review, VI: 1-11

MLA

    MLA : Arshad, Afia, Alia Eum, and Ume Ruqia Tulain. "Role Of Probiotics And Microbiota In Covid-19." Global Drug Design & Development Review, VI.III (2021): 1-11 Print.

OXFORD

    OXFORD : Arshad, Afia, Eum, Alia, and Tulain, Ume Ruqia (2021), "Role Of Probiotics And Microbiota In Covid-19", Global Drug Design & Development Review, VI (III), 1-11

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