ARTICLE

PROSTATE SPECIFIC ANTIGEN AS A TUMOR MARKER IN PROSTATE CANCER EXPLORING BIOCHEMICAL AND CLINICAL ASPECTS

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06 Pages : 35-41

http://dx.doi.org/10.31703/gdddr.2023(VIII-I).06      10.31703/gdddr.2023(VIII-I).06      Published : Mar 2023

Prostate Specific Antigen as a Tumor Marker in Prostate Cancer: Exploring Biochemical and Clinical Aspects

Abstract

    This study explores the role of Prostate Specific Antigen (PSA) as a tumour marker in prostate cancer diagnosis and prognosis.A cohort of 120 participants aged 45 to 70 years underwent a cross-sectional analysis of PSA levels and their correlation with tumour characteristics.Data collection involved structured interviews and medical record reviews. Diagnostic assessments, including histopathological analysis and Gleason scores (6 to 9), were performed. PSA levels were correlated with tumour characteristics. Statistical analysis utilized IBM SPSS Statistics.The distribution of PSA levels (mean: 8.52 ng/mL, median: 7.89 ng/mL) reflected variations. A positive correlation (0.67) existed between PSA levels and Gleason scores. Receiver Operating Characteristic analysis yielded an AUC of 0.82, indicating good diagnostic accuracy.The study provides insights into PSA's diagnostic potential and its correlation with tumour characteristics in prostate cancer.Acknowledging limitations, this research prompts validation efforts to bridge research and clinical understanding.

    Antigen, Tumor Marker, Prostate Cancer, Biochemical, Clinical Aspects,

    (1) Abid Khan
    Lecturer, Khyber Medical University-Institute of Health Sciences, Kohat, KP, Pakistan.
    (2) Muhammad Umar Abid
    Student, Department of Zoology, Government College University, Faisalabad, Punjab, Pakistan.
    (3) Yousaf Mehmood Burki
    Bachelor of Science in Medical Laboratory Technology, Department of Medical Laboratory Technology, Khyber Medical University-Institute of Health Sciences, Kohat, KP, Pakistan.
    (4) Attaullah
    Medical Laboratory Technologist, Talha Clinical Laboratory, Gul Medical Centre, Dargai, Malakand, KP, Pakistan
    (5) Muhammad Zuhair
    Student, Department of Biochemistry, Quaid-e-Azam University, Islamabad, Pakistan.
    (6) Muhammad Haseeb Aftab
    M.Phil. Department of Pharmacy, University of Lahore, Punjab, Pakistan.
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References

  • Bang, S., Yu, J., Chung, J. H., Song, W., Kang, M., Sung, H. H., Jeon, H. G., Jeong, B. C., Seo, S. I., Lee, H. M., & Jeon, S. S. (2021). Usefulness of MRI targeted prostate biopsy for detecting clinically significant prostate cancer in men with low prostate-specific antigen levels. Scientific Reports, 11(1), 21951. https://doi.org/10.1038/s41598-021-00548-4
  • Boesen, L., Nørgaard, N., Løgager, V., Balslev, I., Bisbjerg, R., Thestrup, K.-C., Jakobsen, H., & Thomsen, H. S. (2019). Prebiopsy Biparametric Magnetic Resonance Imaging Combined with Prostate-specific Antigen Density in Detecting and Ruling out Gleason 7–10 Prostate Cancer in Biopsy-naïve Men. European Urology Oncology, 2(3), 311–319. https://doi.org/10.1016/j.euo.2018.09.001
  • Cao, L., Lee, C. H., Ning, J., Handy, B. C., Wagar, E. A., & Meng, Q. H. (2018). Combination of prostate cancer antigen 3 and Prostate- Specific antigen improves diagnostic accuracy in men at risk of prostate cancer. Archives of Pathology & Laboratory Medicine, 142(9), 1106–1112. https://doi.org/10.5858/arpa.2017-0185-oa
  • Carlsson, S. V., Arnsrud Godtman, R., Pihl, C.-G., Vickers, A., Lilja, H., Hugosson, J., & MÃ¥nsson, M. (2023). Young Age on Starting Prostate-specific Antigen Testing Is Associated with a Greater Reduction in Prostate Cancer Mortality: 24-Year Follow- up of the Göteborg Randomized Population- based Prostate Cancer Screening Trial. European Urology, 83(2), 103–109. https://doi.org/10.1016/j.eururo.2022.10.006
  • Catalona, W. J., Richie, J. P., Ahmann, F. R., Hudson, M. A., Scardino, P. T., Flanigan, R. C., DeKernion, J. B., Ratliff, T. L., Kavoussi, L. R., Dalkin, B. L., Waters, W. B., MacFarlane, M. T., & Southwick, P. C. (1994). Comparison of digital rectal examination and serum prostate specific antigen in the early detection of prostate cancer: results of a multicenter clinical trial of 6,630 men. The Journal of Urology, 151(5), 1283–1290. https://doi.org/10.1016/s0022-5347(17)35233-3
  • Choi, H., Cho, S., Bae, J. H., Lee, S. E., Hong, S. K., Moon, D. G., Cheon, J., Byun, S.-S., & Park, J. Y. (2017). Characteristics of Prostate Cancer by Opportunistic Screening in Korean Men with a Prostate-Specific Antigen Level Less Than 4.0 ng per Milliliter. Urologia Internationalis, 99(2), 143–148. https://doi.org/10.1159/000454886
  • De Koning, H. J., Gulati, R., Moss, S., Hugosson, J., Pinsky, P. F., Berg, C. D., Auvinen, A., Andriole, G. L., Roobol, M. J., Crawford, E. D., Nelen, V., Kwiatkowski, M., Zappa, M., Luján, M., Villers, A., De Carvalho, T. M., Feuer, E. J., Tsodikov, A., Mariotto, A. B., . . . Etzioni, R. (2017). The efficacy of prostate- specific antigen screening: Impact of key components in the ERSPC and PLCO trials. Cancer, 124(6), 1197–1206. https://doi.org/10.1002/cncr.31178
  • Ikuerowo, S., Ajala, M., Abolarinwa, A., & Omisanjo, O. (2016). Age-specific serum prostate specific antigen ranges among apparently healthy Nigerian men without clinical evidence of prostate cancer. Nigerian Journal of Surgery, 22(1), 5. https://doi.org/10.4103/1117-6806.169821
  • Ilic, D., Djulbegovic, M., Jung, J. H., Hwang, E. C., Zhou, Q., Cleves, A., Agoritsas, T., & Dahm, P. (2018). Prostate cancer screening with prostate-specific antigen (PSA) test: a systematic review and meta-analysis. BMJ (Clinical Research Ed.), 362, k3519. https://doi.org/10.1136/bmj.k3519
  • Jiao, B., Gulati, R., Hendrix, N., Gore, J. L., Soroush Rais-Bahrami, Morgan, T. M., & Etzioni, R. (2021). Economic Evaluation of Urine-Based or Magnetic Resonance Imaging Reflex Tests in Men With Intermediate Prostate-Specific Antigen Levels in the United States. Value in Health, 24(8), 1111–1117. https://doi.org/10.1016/j.jval.2021.02.009
  • Lavallée, L. T., Binette, A., Witiuk, K., Cnossen, S., Mallick, R., Fergusson, D. A., Momoli, F., Morash, C., Cagiannos, I., & Breau, R. H. (2016). Reducing the Harm of Prostate Cancer Screening: Repeated Prostate- Specific Antigen Testing. Mayo Clinic Proceedings, 91(1), 17–22. https://doi.org/10.1016/j.mayocp.2015.07.030
  • Lee, D. J., Mallin, K., Graves, A. J., Chang, S. S., Penson, D. F., Resnick, M. J., & Barocas, D. A. (2017). Recent Changes in Prostate Cancer Screening Practices and Epidemiology. Journal of Urology, 198(6), 1230–1240. https://doi.org/10.1016/j.juro.2017.05.074
  • Mahal, B. A., Aizer, A. A., Efstathiou, J. A., & Nguyen, P. L. (2015). Association of very low prostate-specific antigen levels with increased cancer-specific death in men with high-grade prostate cancer. Cancer, 122(1), 78–83. https://doi.org/10.1002/cncr.29691
  • Merriel, S. W. D., Pocock, L., Gilbert, E., Creavin, S., Walter, F. M., Spencer, A., & Hamilton, W. (2022). Systematic review and meta- analysis of the diagnostic accuracy of prostate-specific antigen (PSA) for the detection of prostate cancer in symptomatic patients. BMC Medicine, 20(1). https://doi.org/10.1186/s12916-021-02230-y
  • Mottet, N., Bellmunt, J., Bolla, M., Briers, E., Cumberbatch, M., De Santis, M., Fossati, N., Gross, T., Henry, A., Joniau, S., Lam, T., Mason, M. D., Матвеев, Ð’. Б., Moldovan, P. C., Van Den Bergh, R. C., Van Den Broeck, T., Van Der Poel, H. G., Van Der Kwast, T. H., Rouvière, O., . . . Cornford, P. (2017). EAU-ESTRO-SIOG Guidelines on Prostate Cancer. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent. European Urology, 71(4),618–629. https://doi.org/10.1016/j.eururo.2016.08.003
  • Ola, I. O., Talala, K., Tammela, T. L., Taari, K., Murtola, T. J., Kujala, P., Raitanen, J., & Auvinen, A. (2022). Prostate cancer incidence in men with prostate‐specific antigen below 3 ng/ mL : The Finnish Randomized Study of Screening for Prostate Cancer. International Journal of Cancer, 152(4), 672–678. https://doi.org/10.1002/ijc.34274
  • Roth, J. A., Gulati, R., Gore, J. L., Cooperberg, M. R., & Etzioni, R. (2016). Economic Analysis of Prostate-Specific Antigen Screening and Selective Treatment Strategies. JAMA Oncology, 2(7), 890. https://doi.org/10.1001/jamaoncol.2015.6275
  • Spratt, D. E., Dai, D., Den, R. B., Troncoso, P., Yousefi, K., Ross, A. E., Schaeffer, E. M., Haddad, Z., Elai Davicioni, Mehra, R., Morgan, T. M., Rayford, W., Firas Abdollah, Trabulsi, E. J., Achim, M., Li, E., Guerrero, M., R. Jeffrey Karnes, Dicker, A. P., & Hurwitz, M. A. (2018). Performance of a Prostate Cancer Genomic Classifier in Predicting Metastasis in Men with Prostate- specific Antigen Persistence Postprostatectomy. European Urology, 74(1), 107–114. https://doi.org/10.1016/j.eururo.2017.11.024

Cite this article

APA

    APA : Khan, A., Abid, M. U., & Burki, Y. M. (2023). Prostate Specific Antigen as a Tumor Marker in Prostate Cancer: Exploring Biochemical and Clinical Aspects. Global Drug Design & Development Review, VIII(I), 35-41. https://doi.org/10.31703/gdddr.2023(VIII-I).06

CHICAGO

    CHICAGO : Khan, Abid, Muhammad Umar Abid, and Yousaf Mehmood Burki. 2023. "Prostate Specific Antigen as a Tumor Marker in Prostate Cancer: Exploring Biochemical and Clinical Aspects." Global Drug Design & Development Review, VIII (I): 35-41 doi: 10.31703/gdddr.2023(VIII-I).06

HARVARD

    HARVARD : KHAN, A., ABID, M. U. & BURKI, Y. M. 2023. Prostate Specific Antigen as a Tumor Marker in Prostate Cancer: Exploring Biochemical and Clinical Aspects. Global Drug Design & Development Review, VIII, 35-41.

MHRA

    MHRA : Khan, Abid, Muhammad Umar Abid, and Yousaf Mehmood Burki. 2023. "Prostate Specific Antigen as a Tumor Marker in Prostate Cancer: Exploring Biochemical and Clinical Aspects." Global Drug Design & Development Review, VIII: 35-41

MLA

    MLA : Khan, Abid, Muhammad Umar Abid, and Yousaf Mehmood Burki. "Prostate Specific Antigen as a Tumor Marker in Prostate Cancer: Exploring Biochemical and Clinical Aspects." Global Drug Design & Development Review, VIII.I (2023): 35-41 Print.

OXFORD

    OXFORD : Khan, Abid, Abid, Muhammad Umar, and Burki, Yousaf Mehmood (2023), "Prostate Specific Antigen as a Tumor Marker in Prostate Cancer: Exploring Biochemical and Clinical Aspects", Global Drug Design & Development Review, VIII (I), 35-41

TURABIAN

    TURABIAN : Khan, Abid, Muhammad Umar Abid, and Yousaf Mehmood Burki. "Prostate Specific Antigen as a Tumor Marker in Prostate Cancer: Exploring Biochemical and Clinical Aspects." Global Drug Design & Development Review VIII, no. I (2023): 35-41. https://doi.org/10.31703/gdddr.2023(VIII-I).06