The aim of the study was to investigate the relationship between generalized anxiety disorder and cannabis usage within the general population. Furthermore, the study aimed to explore the levels of generalized anxiety disorder among individuals with different demographic characteristics associated with cannabis use. A total of 123 individuals with a history of cannabis use participated in the study. Data were collected from male participants aged 18 and above at the Khyber Teaching Hospital OPD. A standardized Urdu‐translated version of the Generalized Anxiety Disorder (GAD) scale was utilized to assess symptoms of generalized anxiety disorder. The findings revealed that various demographic characteristics, such as younger age, education level, and socioeconomic status, were significantly associated with generalized anxiety disorder. This suggests that younger individuals with lower levels of education and socioeconomic status were more vulnerable to developing anxiety symptoms among cannabis users. The study's findings may be beneficial for targeted interventions and for identifying the challenges faced by individuals from various demographic backgrounds who use cannabis.