ARTICLE

IMPACT OF TYPE 2 DIABETES MELLITUS ON THE SEVERITY OF CORONARY ARTERY DISEASE INSIGHTS FROM ANGIOGRAPHIC ASSESSMENT

05 Pages : 28-34

http://dx.doi.org/10.31703/gdddr.2023(VIII-I).05      10.31703/gdddr.2023(VIII-I).05      Published : Mar 2023

Impact of Type 2 Diabetes Mellitus on the Severity of Coronary Artery Disease: Insights from Angiographic Assessment

    Diabetic people, especially those with diabetes (type 2), have a two- to three-fold greater chance of developing coronary artery disease (CAD) compared to non-diabetics. By assessing the angiograms of diabetic as well as non-diabetic individuals, the current study sought to determine the impact of diabetes mellitus (DM) on the degree and intensity of CAD. This cross-sectional study included 138 male patients out of 1246 patients who underwent coronary angiography for suspected CAD. Type 2 diabetes had been diagnosed in 78 of these patients. fourteen diabetic patients were not found to have CAD. Sixty-four (46.37%) of the diabetic patients and sixty (43.47%) of the non-diabetic patients were found to have CAD and were then examined in the current investigation. Type-2 diabetes demonstrated significantly greater hypertension and age disparities than non-diabetics. Diabetes patients had an increased prevalence of multi-lesion, multivessel, extensive, and relatively small vessel disease than people without diabetes. The left circumflex artery was indeed the coronary artery that was typically frequently affected in diabetes individuals. People who have diabetes (n = 41; 64.7%) had substantially (P = 0.02) greater rates of triple vessel involvement. The structure of the coronary arteries is significantly impacted by diabetes type 2 which is also linked to hypertension, age, and an increased risk of multivessel and severe CAD.

    Type-2 Diabetes, Coronary Heart Disease, Coronary Artery Disease (CAD), Hypertension, Angiography
    (1) Aurang Zeb
    Department of Cardiology, Saidu Teaching Hospital, Swat, KP, Pakistan.
    (2) Hadi Yousaf Saeed
    Assistant Professor of Cardiology, SFMKB Institute of Cardiology, Dera Ghazi Khan, Punjab, Pakistan.
    (3) Sher Wali Khan
    FCPS Resident Adult Cardiology, Lady Reading Hospital, Peshawar, KP, Pakistan.
    (4) Inam-u-llah
    Lecturer, Department of Food Science and Technology, The University of Haripur, KP, Pakistan.
    (5) Madeeha Jadoon
    Assistant Professor of Biochemistry, Women Medical and Dental College, Abbottabad, KP, Pakistan
  • Ahmed, J., Rathi, N., Alam, M. A., Baloch, Z., Munaf, A., Maheshwari, B., Komal Lohana, & Memon, F. (2015). Acute myocardial infarction; a comparative study to assess the angiographic changes in diabetic and non- diabetic patients. The Professional Medical Journal, 22(8), 996–1000. https://doi.org/10.29309/tpmj/2015.22.08.1144
  • Andreini, D., Pontone, G., Bartorelli, A. L., Agostoni, P., Mushtaq, S., Antonioli, L., Cortinovis, S., Canestrari, M., Annoni, A., Ballerini, G., Fiorentini, C., & Pepi, M. (2010). Comparison of the diagnostic performance of 64-slice computed tomography coronary angiography in diabetic and non-diabetic patients with suspected coronary artery disease. Cardiovascular Diabetology, 9(1), 80. https://doi.org/10.1186/1475-2840-9-80
  • Dubey, L., Guruprasad, S., & Subramanyam, G. (2014). Relationship between type 2 diabetes mellitus and coronary artery lesion characteristics: a single centre study. Nepalese Heart Journal, 10(1), 20–22. https://doi.org/10.3126/njh.v10i1.9742
  • Erling F, Valentine F, Predimank S (1998) Interrelationship between atherosclerosis and thrombosis; In Verstrate M, Fuster V, Topol E J, Ed. Cardiovascular thrombosis. Second ed New York, Lippincott Raven: 28- 35.
  • Falk, E. (1991). Coronary thrombosis: Pathogenesis and clinical manifestations. The American Journal of Cardiology, 68(7), B28–B35. https://doi.org/10.1016/0002-9149(91)90382-u
  • Hadamitzky, M., Hein, F., Meyer, T., Bischoff, B., Martinoff, S., Schomig, A., & Hausleiter, J. (2010). Prognostic Value of Coronary Computed Tomographic Angiography in Diabetic Patients Without Known Coronary Artery Disease. Diabetes Care, 33(6), 1358– 1363. https://doi.org/10.2337/dc09-2104
  • Hegde, S. S., Mallesh, P., Yeli, S. M., Gadad, V. M., & M, G. P. (2014). ComComparativegiographic profile in diabetic and non-diabetic patients with acute coronary syndrome. Journal of cliClinicald diagnostic research: CDR, 8(9), MC07– MC10. https://doi.org/10.7860/JCDR/2014/9072.4851
  • Hussein, M. F. (2011). Clinical and angiographic findings in diabetic versus non-diabetic Iraqi patients with ischemic heart disease (A single centre experience). The Iraqi Postgraduate Medical Journal, 10(3), 339-346.
  • Jamee, A., Abed, Y., Ramadan, M., El-Rabia, K., Nasser, G., & Hijazi, M. (2015). Impact of Diabetes Mellitus on Coronary Artery Disease in Women Attending Coronary Angiography in Gaza- Palestine: An Observational Study. Cardiology and Angiology: An International Journal, 4(1), 10– 18. https://doi.org/10.9734/ca/2015/17940
  • Kadhim, A. R., Strak, S. K., & Hazaa, M. A. (2013). Coronary angiographic findings in diabetic patients versus non-diabetics with coronary heart disease. Al-Kindy Col Med J 9(1), 23-30.
  • Krul, G., Bogaard, K., Knol, R. J. J., Albert, Knaapen, P., Cornel, J. H., & van. (2014). Coronary artery disease in patients with atypical chest pain with and without diabetes mellitus assessed with coronary CT angiography. BMJ Open Diabetes Research and Care, 2(1), 1–9. https://doi.org/10.1136/bmjdrc-2013-000004
  • Mahalle, N., Garg, M. K., Naik, S. S. & Kulkarni, M. V. (2014) Association of metabolic syndrome with the severity of coronary artery disease. Indian Journal of Endocrinology and Metabolism, 18(5), 708– 708. https://doi.org/10.4103/2230-8210.139238
  • Mendis, S., Puska, P., & Norrving, B. (2011). Global atlas on cardiovascular disease prevention and control. https://www.cabdirect.org/abstracts/20123402600.html
  • Mohammad, H. N. (2014). Cardiovascular diseases and risk factors among diabetic patients in Nablus district, West Bank, Palestine: Case-control study. M.Sc thesis. An-Najah National University. https://scholar.najah.edu/content/cardiovasculardiseases-and-risk-factors-among-diabeticpatients-nablus-district-west-bank
  • Nathan, D. M., Meigs, J., & Singer, D. E. (1997). The epidemiology of cardiovascular disease in type 2 diabetes mellitus: how sweet it is … or is it? The Lancet, 350(S1), S4–S9. https://doi.org/10.1016/s0140-6736(97)90021-0
  • Parvin, T., Haque, K. S., Siddique, M. A., Habib, S. A., Rahman, M., Rahman, M. H., ... & Hoque, M. H. (2014). Angiographic Severity of Coronary Artery Disease in Diabetic and Non-Diabetic Patients in a Tertiary Care Centre. University Heart Journal, 10(1), 13– 17. https://doi.org/10.3329/uhj.v10i1.24590
  • Rlos, M. (n.d). Cardiac complications in diabetes. World Book of Diabetes in Practice 2: 169
  • Ross, R. (1996). Atherosclerosis — an inflammatory disease. Fibrinolysis, 10, 44. https://doi.org/10.1016/s0268-9499(96)80718-1
  • Sidhu, N. S., Wander, G. S., Monga, A., & Kaur, A. (2019). Incidence, Characteristics and Atherosclerotic Involvement of Coronary Artery Anomalies in Adult Population Undergoing Catheter Coronary Angiography. Cardiology Research, 10(6), 358–368. https://doi.org/10.14740/cr941
  • Sousa, J. M., Herrman, J. L., Teodoro, M., Diogo, S., Terceiro, B. B., Paola, A. A., & Carvalho, A. C. (2006). Comparação da coronariografia de mulheres diabéticas e não-diabéticas com síndrome coronariana aguda sem supradesnivelamento de ST [Comparison of coronary angiography findings in diabetic and non-diabetic women with non-ST- segment-elevation acute coronary syndrome]. Arquivos brasileiros de cardiologia, 86(2), 150–155. h ttps://doi.org/10.1590/s0066-782x2006000200012
  • Srinidhi, S. H., Mallesh, P., Yeli, S. M., Veeranna, M. G., & GiriPunja, M. (2014). Comparative angiographic profile in diabetic and non- diabetic patients with acute coronary syndrome. Journal of Clinical and Diagnostic Research 8(9), 7-10. https://doi.org/10.7860/jcdr/2014/9072.4851
  • Thripaty, B. B. (2001). Complications of diabetes: API textbook of medicine, 6th Edn. Association of Physicians of India: 1005- 1007.
  • WHO. (2002). Reducing risks, promoting healthy life. WHO Report. http://www.who.int/whr/2002/en/
  • WHO. (2005). Preventing chronic diseases–A vital investment. Geneva. http://apps.who.int/iris/bitstream/10665/43314/1/9241563001_eng.pdf
  • WHO. (2007). Prevention of cardiovascular disease: Guidelines for assessment and management of total cardiovascular risk. Geneva: http://www.who.int/cardiovascular_diseases/guidelines/PocketGL.ENGLISH.AFR-D-E.rev1.pdf
  • WHO. (2008). World health statistics 2008. Geneva. http://www.who.int/whosis/whostat/2008/en
  • Wu, T.-G., & Wang, L. (2002). Angiographic characteristics of the coronary artery in patients with type 2 diabetes. Experimental and Clinical Cardiology, 7(4), 199–200. https://pubmed.ncbi.nlm.nih.gov/19644592/
  • Zera, E., Xinxo, S., & Lezha, M. (2015). Comparison of In-Hospital Outcome of Acute Myocardial Infarction in Patients with vs without Diabetes Mellitus in Durres Population. Cardiology and Angiology: An International Journal, 3(3), 130–136. https://doi.org/10.9734/CA/2015/17024

Cite this article

    APA : Zeb, A., Saeed, H. Y., & Khan, S. W. (2023). Impact of Type 2 Diabetes Mellitus on the Severity of Coronary Artery Disease: Insights from Angiographic Assessment. Global Drug Design & Development Review, VIII(I), 28-34. https://doi.org/10.31703/gdddr.2023(VIII-I).05
    CHICAGO : Zeb, Aurang, Hadi Yousaf Saeed, and Sher Wali Khan. 2023. "Impact of Type 2 Diabetes Mellitus on the Severity of Coronary Artery Disease: Insights from Angiographic Assessment." Global Drug Design & Development Review, VIII (I): 28-34 doi: 10.31703/gdddr.2023(VIII-I).05
    HARVARD : ZEB, A., SAEED, H. Y. & KHAN, S. W. 2023. Impact of Type 2 Diabetes Mellitus on the Severity of Coronary Artery Disease: Insights from Angiographic Assessment. Global Drug Design & Development Review, VIII, 28-34.
    MHRA : Zeb, Aurang, Hadi Yousaf Saeed, and Sher Wali Khan. 2023. "Impact of Type 2 Diabetes Mellitus on the Severity of Coronary Artery Disease: Insights from Angiographic Assessment." Global Drug Design & Development Review, VIII: 28-34
    MLA : Zeb, Aurang, Hadi Yousaf Saeed, and Sher Wali Khan. "Impact of Type 2 Diabetes Mellitus on the Severity of Coronary Artery Disease: Insights from Angiographic Assessment." Global Drug Design & Development Review, VIII.I (2023): 28-34 Print.
    OXFORD : Zeb, Aurang, Saeed, Hadi Yousaf, and Khan, Sher Wali (2023), "Impact of Type 2 Diabetes Mellitus on the Severity of Coronary Artery Disease: Insights from Angiographic Assessment", Global Drug Design & Development Review, VIII (I), 28-34
    TURABIAN : Zeb, Aurang, Hadi Yousaf Saeed, and Sher Wali Khan. "Impact of Type 2 Diabetes Mellitus on the Severity of Coronary Artery Disease: Insights from Angiographic Assessment." Global Drug Design & Development Review VIII, no. I (2023): 28-34. https://doi.org/10.31703/gdddr.2023(VIII-I).05