ARTICLE

EFFECTIVENESS OF TIROFIBAN IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION FOR STSEGMENT ELEVATION MYOCARDIAL INFARCTION A METAANALYSIS OF RANDOMIZED CLINICAL TRIALS

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06 Pages : 42-51

http://dx.doi.org/10.31703/gdddr.2022(VII-II).06      10.31703/gdddr.2022(VII-II).06      Published : Jun 2022

Effectiveness of Tirofiban in Patients Undergoing Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Clinical Trials

Abstract

    Whether or whether or not tirofiban is beneficial within side the quick time period for sufferers with STEMI who go through PCI is debatable. A meta-analysis validated the short-term efficacy and safety of tirofiban in patients with ST-phase elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). Comparing STEMI patients undergoing PCI with and without tirofiban. We found all relevant randomised controlled trials by searching scientific databases and websites. This fixed-results model computed RR and 95% CI. 10 RCTs included 5008 people. After 30 days, death from any cause (RR 0.79, CI 0.55-1.12, P=0.18), major bleeding (1.37, 0.93-2.03, P=0.11), or transfusion (1.23, 0.94-1.61, P=0.13) were no longer impacted. Minor bleeding (1.29, 1.02-1.63, P=0.04), thrombocytopenia (2.04, 1.40-2.97, P=0.0002), and 6-month all-purpose mortality (0.57, 0.36-0.90, P=0.02) showed statistically significant differences. Repeat revascularization (0.58, 0.43-0.78, P=0.0004) and myocardial infarction (0.55, 0.33-0.92, P=0.02) also differed. Mild bleeding and thrombocytopenia are more common with tirofiban, although reinfarction, revascularization, and death after 6 months are decreased.

    Tirofiban, Percutaneous Coronary Intervention, ST-Segment Elevation, My0cardial Infarction

    (1) Zia ur Rahman
    MBBS, FCPS, Department of Cardiology, Hayatabad Medical Complex, Peshawar, KP, Pakistan.
    (2) Irfan Ali Khan
    MBBS, FCPS, Department of Cardiology, Hayatabad Medical Complex, Peshawar, KP, Pakistan.
    (3) Qazi Najeeb Ullah Amin
    MBBS, FCPS, Department of Cardiology, Hayatabad Medical Complex, Peshawar, KP, Pakistan.
    (4) Kashif Ullah
    MBBS, FCPS, Department of Cardiology, Hayatabad Medical Complex, Peshawar, KP, Pakistan.
    (5) Farman Ullah
    MBBS, FCPS, Department of Cardiology, Hayatabad Medical Complex, Peshawar, KP, Pakistan.
    (6) Sami Ullah
    MBBS, FCPS, Department of Cardiology, Hayatabad Medical Complex, Peshawar, KP, Pakistan.
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Cite this article

APA

    APA : Rahman, Z. u., Khan, I. A., & Amin, Q. N. U. (2022). Effectiveness of Tirofiban in Patients Undergoing Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Clinical Trials. Global Drug Design & Development Review, VII(II), 42-51. https://doi.org/10.31703/gdddr.2022(VII-II).06

CHICAGO

    CHICAGO : Rahman, Zia ur, Irfan Ali Khan, and Qazi Najeeb Ullah Amin. 2022. "Effectiveness of Tirofiban in Patients Undergoing Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Clinical Trials." Global Drug Design & Development Review, VII (II): 42-51 doi: 10.31703/gdddr.2022(VII-II).06

HARVARD

    HARVARD : RAHMAN, Z. U., KHAN, I. A. & AMIN, Q. N. U. 2022. Effectiveness of Tirofiban in Patients Undergoing Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Clinical Trials. Global Drug Design & Development Review, VII, 42-51.

MHRA

    MHRA : Rahman, Zia ur, Irfan Ali Khan, and Qazi Najeeb Ullah Amin. 2022. "Effectiveness of Tirofiban in Patients Undergoing Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Clinical Trials." Global Drug Design & Development Review, VII: 42-51

MLA

    MLA : Rahman, Zia ur, Irfan Ali Khan, and Qazi Najeeb Ullah Amin. "Effectiveness of Tirofiban in Patients Undergoing Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Clinical Trials." Global Drug Design & Development Review, VII.II (2022): 42-51 Print.

OXFORD

    OXFORD : Rahman, Zia ur, Khan, Irfan Ali, and Amin, Qazi Najeeb Ullah (2022), "Effectiveness of Tirofiban in Patients Undergoing Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Clinical Trials", Global Drug Design & Development Review, VII (II), 42-51

TURABIAN

    TURABIAN : Rahman, Zia ur, Irfan Ali Khan, and Qazi Najeeb Ullah Amin. "Effectiveness of Tirofiban in Patients Undergoing Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Meta-Analysis of Randomized Clinical Trials." Global Drug Design & Development Review VII, no. II (2022): 42-51. https://doi.org/10.31703/gdddr.2022(VII-II).06