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An Insight About the Drug Release Mechanisms from Different Dosage Forms

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Abstract

A process in which drug comes out from drug product and exposed to ADME and finally become accessible for pharmacological activity is known as drug release and mechanism involves the study of its rate and factors influencing its rate. Factors influencing the rate of drug release are drug related, polymer related and formulation variables. Drug delivery systems are discriminated on the basis of way drug is delivered, which are immediate release and modified release. Parenteral dosage forms are the most prominent among different dosage forms. The mechanisms involved in drug release are diffusion and dissolution-controlled processes. Nasal disposal basically depends on the particle size, its geometry and rate of airflow. Nasal sprays are commonly used than powders and gels. Buccal and sublingual systems show more effective drug release mechanisms than oral and transdermal systems. Main focus of paper is to elaborate different mechanisms performed by drug delivery systems for drug release.

Authors

1-Hafsa Shahid
a Undergraduate Students (Final year), Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

2-Ayesha Ahmed
Undergraduate Students (Final year), Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

3-Ammarah Ashraf
Undergraduate Students (Final year), Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

4-Nida Rashid
d Undergraduate Students (Final year), Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

5-Mubashir Rehman
Assistant Professor, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Keywords

Drug Release Mechanisms, Dosage Forms, Drugs, Parenteral, Diffusion

DOI Number

10.31703/gdddr.2016(I-I).01


Page Nos

1-8

Volume & Issue

I - I

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Published: Dec 2016

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