References

• Bouzom, F., Ball, K., Perdaems, N., & Walther, B. (2012). Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs? Biopharmaceutics & Drug Disposition, 33(2), 55-71. doi: 10.1002/bdd.1767.
• Edginton, A., & Joshi, G. (2011). Have physiologically based pharmacokinetic models delivered? Expert Opinion on Drug Metabolism & Toxicology, 7(8), 929-934. doi: 10.1517/17425255.2011.585968.
• Espié, P., Tytgat, D., Sargentini-Maier, M., Poggesi, I., & Watelet, J. (2009). Physiologically based pharmacokinetics (PBPK). Drug Metabolism Reviews, 41(3), 391-407. doi: 10.1080/10837450902891360
• Holdford, D., Huang, X., & Zheng, Q. (2010). Renee J. G. Arnold (Editor). Pharmacoeconomics: From Theory to Practice. Boca Raton, FL: CRC Press: 2009. 264 pp, $119.95, ISBN-13: 978- 1420084221. Johan Gabrielsson, Daniel Weiner. Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Fourth Edition. Sweden: Swedish Pharmaceutical Press; 2007. 1250 pages; $199.95 (hardcover). ISBN: 9197651001. American Journal of Pharmaceutical Education, 74(3), 53. doi: 10.5
• Howlett, S. (). FRAILTY AND BIOLOGICAL AGE IN ANIMAL MODELS. Innovation in Aging, 2(suppl_1), 836-836. doi: 10.1093/geroni/igy023.3115.
• Jones, H., & Rowland-Yeo, K. (2013). Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development. CPT: Pharmacometrics & Systems Pharmacology, 2(8), 63. doi: 10.1038/psp.2013.41.
• McGlynn, B., McDonnell, J., Stewart, M., & Seibert, J. (2002). On the relationships between catchment scale and stream water mean residence time. Hydrological Processes, 17(1), 175-181. doi: 10.1002/hyp.5085.
• Nestorov, I. (2003). Whole Body Pharmacokinetic Models. Clinical Pharmacokinetics, 42(10), 883-908. doi: 10.2165/00003088- 200342100-00002.
• Niederalt, C., Kuepfer, L., Solodenko, J., Eissing, T., Siegmund, H., & Block, M. et al. (). A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim. Journal of Pharmacokinetics and Pharmacodynamics, 45(2), 235-257. doi: 10.1007/s10928-017-9559-4.
• Parrott, N., & Lave, T. (2008). Applications of Physiologically Based Absorption Models in Drug Discovery and Development. Molecular Pharmaceutics, 5(5), 760-775. doi: 10.1021/mp8000155.
• Poulin, P., & Theil, F. (2000). A Priori Prediction of Tissue: Plasma Partition Coefficients of Drugs to Facilitate the Use of Physiologically Based Pharmacokinetic Models in Drug Discovery. Journal of Pharmaceutical Sciences, 89(1), 16-35. doi: 10.1002/1520- 6017(200001)89: 116: aid-jps3
• Purves, R. (1992). Optimum numerical integration methods for estimation of area-under-the- curve (AUC) and area-under-the-moment- curve (AUMC). Journal of Pharmacokinetics and Biopharmaceutics, 20(3), 211-226. doi: 10.1007/bf01062525.
• Reineke, J., Li, M., & Avgoustakis, K. (2012). Physiologically based pharmacokinetic modeling of PLGA nanoparticles with varied mPEG content. International Journal of Nanomedicine, 1345. doi: 10.2147/ijn. s23758.
• Riegelman, S., & Collier, P. (1980). The application of statistical moment theory to the evaluation ofin vivo dissolution time and absorption time. Journal of Pharmacokinetics and Biopharmaceutics, 8(5), 509-534. doi: 10.1007/bf01059549.
• Sager, J., Yu, J., Ragueneau-Majlessi, I., & Isoherranen, N. (2015). Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation Approaches: A Systematic Review of Published Models, Applications, and Model Verification. Drug Metabolism and Disposition, 43(11), 1823-1837. doi: 10.1124/dmd.115.065920.
• Sander, L. (2000). Diffusion-limited aggregation: A kinetic critical phenomenon? Contemporary Physics, 41(4), 203-218. doi: 10.1080/001075100409698.
• Siccardi, M., Rannard, S., & Owen, A. (). The emerging role of physiologically based pharmacokinetic modelling in solid drug nanoparticle translation. Advanced Drug Delivery Reviews, 131, 116-121. doi: 10.1016/j.addr.06.016.
• Wang, Z., Kim, S., Quinney, S., Zhou, J., & Li, L. (2010). Non-compartment model to compartment model pharmacokinetics transformation meta-analysis - a multivariate nonlinear mixed model. BMC Systems Biology, 4(S1). doi: 10.1186/1752-0509-4-s1- s8.
• Wright, W. (1994). When Medicine Went Mad: Bioethics and the Holocaust. Arthur L. Caplan (ed.). Totowa, NJ: Humana Press, 1992, 359 pp. US$22.50. ISBN 0-89603-235-3. Humana Press, 999 Riverview Dr., Suite 208, Totowa,NJ 07512, USA. Politics and The Life Sciences, 13(2), 289-291. doi: 10.1017/s0730938400018670.
• Yoshida, K., Budha, N., & Jin, J. (). Impact of Physiologically Based Pharmacokinetic Models on Regulatory Reviews and Product Labels: Frequent Utilization in the Field of Oncology. Clinical Pharmacology & Therapeutics, 101(5), 597-602. doi: 10.1002/cpt.622.