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Bio-Adhesive Nanomedicine for Targeted Drug Delivery

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Abstract

The bio/muco-adhesive auxiliary agents are considered as a promising strategy for the administration of various challenging drugs including peptides, proteins and oligosaccharides therapeutics. The delivery of such therapeutics is hampered due to rapid degradation, restricted uptake, short residence time, poor solubility and limited half-life. The recent emergence of nanomedicine based on bio/mucoadhesive auxiliary agents is offering new avenues to overcome these drawbacks. Hence, it is important to understand the mechanism of nanoscale bio/mucoadhesion, protocols for investigating bio/mucoadhesive potential at nanoscale. This chapter is an endeavor to focus on the mechanism of bio adhesion and the bio/mucoadhesive auxiliary agents that are used in the design of the targeted oral, nasal, ocular, vaginal, and buccal nanomedicine with their properties that affect the bio/mucoadhesion.

Authors

1-Ali Iqbal
M.Phil Candidate, Department of Life Sciences, Faculty of Pharmacy, University of Hertfordshire, Hatfield, United Kingdom UK.

2-Ramsha Malik
M. Phil Candidate, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

3-Malik Irfan Zulfiqar
BS Biotechnology Scholar, Department of Biological Sciences, International Islamic University, Islamabad, Pakistan.

4-Maria Hassan Kiani
PhD Candidate, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

5-Muhammad Rauf ul Hassan
Associate Professor, Department of Pulmonology, Quaid-i-Azam Medical College, Bahawalpur Victoria Hospital, Bahawalpur, Punjab, Pakistan.

Keywords

Bio Adhesion, Mucoadhesion, Nano Cargoes, Polymers, Targeted Drug Delivery System

DOI Number

10.31703/gdddr.2019(IV-I).02


Page Nos

10-23

Volume & Issue

IV - I

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Published: Dec 2019

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